Department of Physiotherapy and Department of Intensive Care, Monash Medical Centre, Southern Health, Clayton, Victoria, Australia.
Crit Care Med. 2011 Aug;39(8):1896-905. doi: 10.1097/CCM.0b013e31821b8421.
To document health-related quality of life of an Australian sample of intensive care unit survivors 6 months after intensive care unit discharge and compare this with preadmission health-related quality of life, health-related quality of life of national population norms, and international samples of intensive care unit survivors.
Prospective observational single-center study.
Eighteen-bed medical-surgical tertiary intensive care unit of an Australian metropolitan hospital.
Of the 122 eligible patients, 100 were recruited (intensive care unit length of stay >48 hrs, age >18 yrs, not imminently at risk of death) and the final sample comprised 67 patients, age (median [interquartile range], 61 yrs [49-73 yrs]), 60% male admitted to the intensive care unit for a median [interquartile range] 101 hrs (68-149 hrs). Normative age- and sex-matched Australian Short-Form 36 data from the Australian Bureau of Statistics, selected international cohorts of intensive care unit survivors, and their respective national age-matched normative data were included for comparison.
None.
Sixty-seven participants provided responses to questions rating health-related quality of life (Australian Short-Form 36) at preadmission (on admission to the intensive care unit or through retrospective recall as soon as able) and 6 months after intensive care unit discharge. Ten additional participants were unable to provide study data without proxy input and were excluded from analysis. Participants reported clinically meaningful improvements in bodily pain (p = .001), social functioning (p = .03), role-emotional domains of the Short-Form 36 (p = .04), and mental component summary score (p = .01) at 6 months after intensive care unit discharge, mostly attributable to the patients undergoing cardiac surgery, whereas remaining Short-Form 36 domains showed no difference between preadmission and 6 months (p > .05). Participants reported clinically meaningful decrements in preadmission Short-Form 36 data compared with the Australian normative population with role-physical (p < .001) and physical functioning (p < .001) most affected at follow-up. Health-related quality of life in this sample was comparable with international samples of intensive care unit survivors.
Although the majority of health-related quality of life domains did not differ between preadmission and 6-month follow-up, participants reported significant and clinically meaningful improvements in pain and mental health at follow-up. Critical illness survivors' health-related quality of life remained within 1 sd of Australian norms at follow-up and physical function health-related quality of life was most affected. Health-related quality of life in these Australian survivors of the intensive care unit was comparable with international survivors 6 months after intensive care unit admission.
在重症监护病房（ICU）出院后 6 个月，记录澳大利亚 ICU 幸存者的健康相关生活质量，并将其与入院前的健康相关生活质量、全国人口健康相关生活质量标准以及国际 ICU 幸存者样本进行比较。
前瞻性观察性单中心研究。
澳大利亚大都市医院的 18 张病床的内科-外科重症监护病房。
在 122 名合格患者中，招募了 100 名（ICU 住院时间>48 小时，年龄>18 岁，无即刻死亡风险），最终样本包括 67 名患者，年龄（中位数[四分位数范围]，61 岁[49-73 岁]），60%为男性，在 ICU 住院的中位数[四分位数范围]为 101 小时[68-149 小时]。包括来自澳大利亚统计局的年龄和性别匹配的澳大利亚简短形式 36 数据、选定的国际 ICU 幸存者队列及其各自的国家年龄匹配的标准数据，以进行比较。
无。
67 名参与者在入院前（入住 ICU 时或尽快通过回顾性回忆）和 ICU 出院后 6 个月时对健康相关生活质量（澳大利亚简短形式 36）问题做出了回应。另外 10 名参与者无法提供研究数据，没有代理输入，因此被排除在分析之外。参与者报告说，身体疼痛（p =.001）、社会功能（p =.03）、短期形式 36 的角色情感领域（p =.04）和心理成分综合评分（p =.01）在 ICU 出院后 6 个月时均有临床意义的改善，主要归因于接受心脏手术的患者，而其余短期形式 36 领域在入院前和 6 个月之间没有差异（p>.05）。与澳大利亚标准人群相比，参与者在入院前的短期形式 36 数据中报告了有临床意义的下降，其中角色身体（p<.001）和身体功能（p<.001）在随访时受影响最大。该样本的健康相关生活质量与国际 ICU 幸存者样本相当。
尽管大多数健康相关生活质量领域在入院前和 6 个月随访之间没有差异，但参与者报告说，疼痛和心理健康在随访时有显著的和有临床意义的改善。危重病幸存者的健康相关生活质量在随访时仍保持在澳大利亚标准的 1 个标准差内，身体功能健康相关生活质量受影响最大。这些澳大利亚 ICU 幸存者的健康相关生活质量与 ICU 入住后 6 个月的国际幸存者相当。
