University de Bordeaux, Interdisciplinary Institute for Neuroscience, Bordeaux, France.
Nat Neurosci. 2011 Jun;14(6):691-3. doi: 10.1038/nn.2809. Epub 2011 May 1.
Hippocampal mossy fiber synapses have been reported to lack NMDA receptor (NMDAR)-dependent long-term potentiation (LTP) of AMPA excitatory postsynaptic currents (EPSCs), unlike conventional glutamatergic synapses. An explanation for this difference may reside in the relatively low number of NMDARs at these synapses. Because mossy fiber synapses display LTP selective for NMDARs, we examined whether this would affect the plasticity rules at mossy fiber-CA3 synapses in mouse hippocampal slices. We found that LTP of NMDARs serves as a metaplastic switch making mossy fiber synapses competent for generating NMDAR-dependent LTP of AMPA EPSCs.
海马苔藓纤维突触被报道缺乏 NMDA 受体 (NMDAR) 依赖性 AMPA 兴奋性突触后电流 (EPSC) 的长时程增强 (LTP)，这与传统的谷氨酸能突触不同。造成这种差异的一个解释可能在于这些突触中 NMDAR 的相对数量较少。由于苔藓纤维突触显示出对 NMDAR 具有选择性的 LTP，我们研究了这种情况是否会影响小鼠海马切片中苔藓纤维-CA3 突触的可塑性规则。我们发现，NMDAR 的 LTP 充当着一种超塑转换开关，使苔藓纤维突触能够产生依赖 NMDAR 的 AMPA EPSC 的 LTP。
