Department of Internal Medicine, Kangbuk Samsung Hospital, Seoul, Korea.
J Korean Med Sci. 2011 May;26(5):697-700. doi: 10.3346/jkms.2011.26.5.697. Epub 2011 Apr 21.
High-mobility group box 1 (HMGB1) protein has been demonstrated to play an important role in chronic inflammatory diseases including rheumatoid arthritis, and systemic lupus erythematosus. This study investigated the association between extracellular HMGB1 expression and disease activity, and clinical features of Behçet's disease (BD). Extracellular HMGB1 expression in the sera of 42 BD patients was measured and was compared to that of 22 age- and sex-matched healthy controls. HMGB1 expression was significantly increased in BD patients compared to healthy controls (78.70 ± 20.22 vs 10.79 ± 1.90 ng/mL, P = 0.002). In addition, HMGB1 expression was significantly elevated in BD patients with intestinal involvement compared to those without (179.61 ± 67.95 vs 61.89 ± 19.81 ng/mL, P = 0.04). No significant association was observed between HMGB1 concentration and other clinical manifestations, or disease activity. It is suggested that extracellular HMGB1 may play an important role in the pathogenesis of BD.
高迁移率族蛋白 B1（HMGB1）蛋白已被证明在包括类风湿关节炎和系统性红斑狼疮在内的慢性炎症性疾病中发挥重要作用。本研究探讨了细胞外 HMGB1 表达与贝赫切特病（BD）的疾病活动度和临床特征之间的关系。测量了 42 例 BD 患者和 22 名年龄和性别匹配的健康对照者血清中的细胞外 HMGB1 表达，并进行了比较。与健康对照组相比，BD 患者的 HMGB1 表达明显升高（78.70 ± 20.22 与 10.79 ± 1.90 ng/mL，P = 0.002）。此外，与无肠道受累的 BD 患者相比，有肠道受累的 BD 患者的 HMGB1 表达明显升高（179.61 ± 67.95 与 61.89 ± 19.81 ng/mL，P = 0.04）。HMGB1 浓度与其他临床表现或疾病活动度之间无显著相关性。提示细胞外 HMGB1 可能在 BD 的发病机制中发挥重要作用。
