Roberts James M, Bodnar Lisa M, Patrick Thelma E, Powers Robert W
Magee-Womens Research Institute, University of Pittsburgh.
Pregnancy Hypertens. 2011 Jan 1;1(1):6-16. doi: 10.1016/j.preghy.2010.10.013.
The incidence of obesity is increasing at an alarming rate. There is compelling evidence that obesity increases the risk of preeclampsia about 3-fold, and in developed countries is the leading attributable risk for the disorder. In this presentation we explore this relationship and propose targets for future studies guided by the much more extensively studied relationship of obesity to cardiovascular disease. We further address the hypothesis that asymmetric dimethyl arginine (ADMA), an endogenous inhibitor of nitric oxide synthase, may be one convergence point for the mechanism by which obesity increases the risk of preeclampsia. We conclude with consideration of the clinical implications of this information.
肥胖症的发病率正以惊人的速度上升。有确凿证据表明，肥胖使先兆子痫的风险增加约3倍，在发达国家，肥胖是该疾病的主要归因风险因素。在本报告中，我们探讨了这种关系，并以对肥胖与心血管疾病关系的更广泛研究为指导，提出了未来研究的目标。我们还进一步探讨了一个假说，即不对称二甲基精氨酸（ADMA），一种一氧化氮合酶的内源性抑制剂，可能是肥胖增加先兆子痫风险机制的一个交汇点。最后，我们考虑了这些信息的临床意义。
