Geria Aanand N, Lawson Christina N, Halder Rebat M
Department of Dermatology, Howard University College of Medicine, Washington, DC 20060, USA.
J Drugs Dermatol. 2011 May;10(5):483-9.
Topical retinoids are an important class of drugs for treating several dermatoses occurring more frequently in patients with pigmented skin, such as melasma, post-inflammatory hyperpigmentation, pseudofolliculits barbae and keloids. They also play a role in managing acne, psoriasis, photoaging, cutaneous T-cell lymphoma, Kaposi sarcoma and disorder of hyperkeratosis in this demographic as well. In general, topical retinoids are well tolerated in pigmented skins. There is little evidence to suggest that patients with darker skin are at increased risk of irritation. However, retinoid dermatitis can induce post-inflammatory hyperpigmentation and attempts should be made to reduce its occurrence by modifying treatment regimens in patients with pigmented skins.
外用维甲酸类药物是治疗多种皮肤病的重要药物类别,这些皮肤病在有色人种患者中更为常见,如黄褐斑、炎症后色素沉着、须部假性毛囊炎和瘢痕疙瘩。它们在治疗该人群的痤疮、银屑病、光老化、皮肤T细胞淋巴瘤、卡波西肉瘤和角化过度疾病方面也发挥作用。一般来说,外用维甲酸类药物在有色人种皮肤中耐受性良好。几乎没有证据表明肤色较深的患者有更高的刺激风险。然而,维甲酸皮炎可诱发炎症后色素沉着,应尝试通过调整有色人种皮肤患者的治疗方案来减少其发生。