氢氧化钾/二甲基亚砜促进的分子内环化反应合成苯并咪唑-2-酮。
Potassium hydroxide/dimethyl sulfoxide promoted intramolecular cyclization for the synthesis of benzimidazol-2-ones.
机构信息
Institute of Organic Chemistry, RWTH Aachen University, Aachen, Germany.
出版信息
Org Lett. 2011 Jun 3;13(11):2876-9. doi: 10.1021/ol2008878. Epub 2011 May 2.
PMID:21534616
Abstract
A new protocol for intramolecular N-arylations of ureas to form benzimidazol-2-ones has been developed. The cyclization reaction occurs in the presence of KOH and DMSO at close to ambient temperature. Under these conditions the yields are high and a wide range of functional groups are tolerated.
摘要
一种新的脲类分子内 N-芳基化形成苯并咪唑-2-酮的方法已经被开发出来。该环化反应在 KOH 和 DMSO 的存在下，于接近环境温度的条件下进行。在这些条件下，产率很高，并且可以容忍广泛的官能团。
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