Department of Biochemistry, Cell and Molecular Biology of Plants, Estación Experimental del Zaidín, CSIC , Granada, Spain .
Antioxid Redox Signal. 2011 Oct 15;15(8):2383-91. doi: 10.1089/ars.2011.4007. Epub 2011 Jun 24.
Dr. Christine Foyer (B.Sc. 1974; Ph.D. 1977) is recognized here as a Redox Pioneer because she has published an article on redox biology that has been cited more than 1000 times, 4 other articles that have been cited more than 500 times, and a further 32 articles that have been each cited more than 100 times. During her Ph.D. at the Kings College, University of London, United Kingdom, Dr. Foyer discovered that ascorbate and glutathione and enzymes linking NADPH, glutathione, and ascorbate are localized in isolated chloroplast preparations. These observations pioneered the discovery of the ascorbate-glutathione cycle, now known as Foyer-Halliwell-Asada pathway after the names of the three major contributors, a crucial mechanism for H(2)O(2) metabolism in both animals and plants. Dr. Foyer has made a very significant contribution to our current understanding of the crucial roles of ascorbate and glutathione in redox biology, particularly in relation to photosynthesis, respiration, and chloroplast and mitochondrial redox signaling networks. "My view is that science…is compulsive and you have to keep with it all the time and not get despondent when things do not work well. Being passionate about science is what carries you through the hard times so that it isn't so much work, as a hobby that you do for a living. It is the thrill of achieving a better understanding and finding real pleasure in putting new ideas together, explaining data and passing on knowledge that keeps you going no matter what!" --Prof. Christine Helen Foyer.
克里斯汀·福耶博士(1974 年获得理学学士学位,1977 年获得博士学位)在此被公认为氧化还原生物学领域的先驱,因为她发表了一篇关于氧化还原生物学的文章,这篇文章被引用了 1000 多次,另有 4 篇文章被引用了 500 多次,还有 32 篇文章被引用了 100 多次。在英国伦敦国王学院攻读博士学位期间,福耶博士发现抗坏血酸和谷胱甘肽以及将 NADPH、谷胱甘肽和抗坏血酸联系起来的酶都定位于分离的叶绿体制剂中。这些观察结果开创了发现抗坏血酸-谷胱甘肽循环的先河,现在这个循环被称为福耶-哈里斯-阿萨达途径,以三位主要贡献者的名字命名,这是动物和植物中 H2O2 代谢的关键机制。福耶博士对我们目前对抗坏血酸和谷胱甘肽在氧化还原生物学中的关键作用的理解做出了非常重要的贡献,特别是与光合作用、呼吸作用以及叶绿体和线粒体氧化还原信号网络有关。“我的观点是,科学……是强制性的,你必须一直跟上它的步伐,当事情不顺利时,不要感到沮丧。对科学充满热情是你克服困难时期的动力,这样它就不再是一项工作,而是你为了生计而做的一项爱好。实现更好的理解并从新想法的结合中获得真正的乐趣,解释数据并传递知识,这才是让你不断前进的动力,无论发生什么!”——克里斯汀·海伦·福耶教授。