Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Meibergdreef 5, 1105AZ Amsterdam, Netherlands.
Biol Psychol. 2011 Jul;87(3):350-7. doi: 10.1016/j.biopsycho.2011.04.005. Epub 2011 Apr 30.
We investigated the course of Event Related Potentials (ERP) from prior to until shortly after a first psychotic episode in subjects at Ultra High Risk (UHR) for psychosis. N1, N2, N2b, P2 and P3 amplitudes were assessed using an auditory active oddball paradigm in 15 UHR subjects who made a transition to psychosis (UHR+T) at follow up, 23 subjects without a transition (UHR+NT) and 17 matched healthy controls at inclusion and again after approximately 18 months. Repeated-measures analyses revealed no significant time effects for any of the ERP components. However, an interaction effect was found for N1 amplitudes. Post-hoc analyses showed that N1 amplitudes were smaller at follow up compared to baseline only in UHR+T subjects. P3 amplitudes showed no further reduction after psychotic onset. These findings suggest that discernable ERP components behave differently during progression from the prodromal phase to the first psychotic episode. These findings may give insight in pathophysiological mechanisms underlying the genesis of psychosis.
我们研究了首发精神病高危人群（UHR）在首次精神病发作前后的事件相关电位（ERP）的变化过程。在随访中，我们使用听觉主动Oddball 范式评估了 15 名发展为精神病的 UHR 受试者（UHR+T）、23 名未发生转变的 UHR 受试者（UHR+NT）和 17 名匹配的健康对照组在入组时和大约 18 个月后的 N1、N2、N2b、P2 和 P3 振幅。重复测量分析显示，任何 ERP 成分均无显著的时间效应。然而，我们发现 N1 振幅存在交互效应。事后分析显示，只有 UHR+T 受试者在随访时的 N1 振幅较基线时降低。精神病发作后 P3 振幅无进一步降低。这些发现表明，从前驱期到首次精神病发作的进展过程中，可区分的 ERP 成分表现不同。这些发现可能有助于了解精神病发生的病理生理机制。
