Department of Medical Genetics, Third Military Medical University, Gaotanyan St., Shapingba District, Chongqing, 400038, People's Republic of China.
Int J Colorectal Dis. 2011 Sep;26(9):1099-105. doi: 10.1007/s00384-011-1198-4. Epub 2011 May 3.
Matrix metalloproteinases (MMPs) play important roles in pathogenesis and development of cancer. Recently, lots of studies showed that there were associations between polymorphisms in the promoter regions of MMPs and risk of colorectal cancer; however, the results remained inconclusive. To clarify these associations, we conducted a meta-analysis.
We conducted a computerized literature search in the database of PubMed, Embase, ISI Web of Knowledge, and Medline (from January 2000 to July 2010). Overall and subgroup analysis based on the ethnicity of study population was carried out. Odds ratio (OR) and 95% confidence interval (95%CI) were used to evaluate these associations. Statistical analysis was performed with software Review Manager (version 5.0).
There were 12 studies involving five polymorphic sites in four MMP genes. For MMP1 (-1607), 2G polymorphism increased the risk of colorectal cancer under dominant and recessive models (dominant, OR = 1.23, 95%CI 1.01-1.49; recessive, OR = 1.52, 95%CI 1.30-1.77). For MMP3 (-1612), 6A/6A genotype increased this risk under the recessive model (OR = 1.33, 95%CI 1.04-1.70); however, this association was lost under the dominant model. For MMP2 -1306 C>T, MMP3 -1171 5A>6A, and MMP9 -1562 C>T, there was no association between these polymorphisms and the risk of colorectal cancer under the dominant and recessive models.
Polymorphisms of MMP1 (-1607) and MMP3 (-1612) increased the risk of colorectal cancer; these two polymorphic sites could be used as markers for early diagnosis of colorectal cancer. However, for MMP2 (-1306), MMP3 (-1171), and MMP9 (-1562), further studies with large sample size should be carried out.
基质金属蛋白酶（MMPs）在癌症的发病机制和发展中发挥着重要作用。最近，许多研究表明 MMPs 启动子区域的多态性与结直肠癌的风险之间存在关联；然而，结果仍存在争议。为了阐明这些关联，我们进行了一项荟萃分析。
我们在 PubMed、Embase、ISI Web of Knowledge 和 Medline 数据库中进行了计算机检索（检索时间为 2000 年 1 月至 2010 年 7 月）。根据研究人群的种族进行了总体和亚组分析。采用比值比（OR）和 95%置信区间（95%CI）来评估这些关联。使用软件 Review Manager（版本 5.0）进行统计分析。
共有 12 项研究涉及 4 个 MMP 基因中的 5 个多态性位点。对于 MMP1（-1607），2G 多态性在显性和隐性模型下增加了结直肠癌的风险（显性，OR=1.23，95%CI 1.01-1.49；隐性，OR=1.52，95%CI 1.30-1.77）。对于 MMP3（-1612），6A/6A 基因型在隐性模型下增加了这种风险（OR=1.33，95%CI 1.04-1.70）；然而，在显性模型下，这种关联就不存在了。对于 MMP2-1306 C>T、MMP3-1171 5A>6A 和 MMP9-1562 C>T，这些多态性与结直肠癌的风险在显性和隐性模型下没有关联。
MMP1（-1607）和 MMP3（-1612）的多态性增加了结直肠癌的风险；这两个多态性位点可作为结直肠癌早期诊断的标志物。然而，对于 MMP2（-1306）、MMP3（-1171）和 MMP9（-1562），还需要进行更大样本量的研究。
