Nowak D, Brüch M, Arnaud F, Fabel H, Kiessling D, Nolte D, Overlack A, Rolke M, Ulmer W T, Worth H
Krankenhaus Grosshansdorf, Zentrum für Pneumologie and Thoraxchirurgie, LVA Hamburg, Federal Republic of Germany.
Lung. 1990;168(1):43-51. doi: 10.1007/BF02719672.
To investigate the prevalence and type of peripheral neuropathies (PNP) in patients with chronic obstructive pulmonary disease (COPD), we studied lung function and blood gases, clinical signs of PNP, and neurophysiological function in 151 patients with COPD without known risk factors for PNP. Mean (SD) age was 65 (10) years, mean arterial PO2 was 59 (9) mmHg, mean ratio of forced expiratory volume in the first second to vital capacity (FEV1.0/VC) was 42 (12%). Thirty patients (20%) had clinically detectable and 6 (4%) had subclinical PNP of mild degree. Fourteen (9%) of the patients with clinically detectable PNP had symptoms due to PNP. Prevalence of PNP increased with severity of hypoxemia (p less than 0.05) and was more pronounced in the lower than in the upper limbs. Age and the degree of hypoxemia were predictors to differentiate between COPD patients with and without PNP. Although the cause of PNP in COPD patients remains unknown, our observations suggest that chronic hypoxemia may contribute to PNP.
为了调查慢性阻塞性肺疾病（COPD）患者周围神经病变（PNP）的患病率及类型，我们对151例无已知PNP危险因素的COPD患者的肺功能、血气、PNP的临床体征及神经生理功能进行了研究。平均（标准差）年龄为65（10）岁，平均动脉血氧分压为59（9）mmHg，第一秒用力呼气容积与肺活量的平均比值（FEV1.0/VC）为42（12%）。30例（20%）患者有临床可检测到的PNP，6例（4%）有轻度亚临床PNP。14例（9%）有临床可检测到PNP的患者有PNP相关症状。PNP的患病率随低氧血症严重程度增加（p<0.05），且在下肢比在上肢更明显。年龄和低氧血症程度是区分有和无PNP的COPD患者的预测因素。虽然COPD患者PNP的病因尚不清楚，但我们的观察结果提示慢性低氧血症可能导致PNP。
