Kiessling D, Langenbahn H, Fabel H, Magnussen H, Nolte D, Overlack A, Ulmer W T, Worth H
Abt. Pneumologie, Medizinische Hochschule, Hannover.
Pneumologie. 1990 Feb;44 Suppl 1:441-3.
A multicentric study of 151 COLD patients confirmed the increased prevalence of peripheral polyneuropathies (PNP) in hypoxaemic patients with chronic obstructive lung disease (COLD). 43 (28%) of these 151 COLD patients showed a clinically manifest PNP, whereas in a comparative group of 32 asthmatics there were only 2 clinical PNP cases. Patients with known risk factors for PNP were not included in the study. The polyneuropathy observed in such patients is usually mild, mainly sensorial, distal and leg-accentuated. Of 52 COLD patients with a PaO2 up to 55 Torr, polyneuropathy was seen in 21 (40%), and of 59 COLD patients with a PaO2 above 60 Torr, 10 (17%) had polyneuropathy. In multifactorial genesis (as would be expected), the degree of severity of hypoxaemia (calculated as reduction of the actual PaO2 value below the age-adjusted nominal value), as well as the age of the patient, are statistically significant predictors of clinically manifest PNP.
一项针对151例慢性阻塞性肺疾病（COLD）患者的多中心研究证实，低氧血症型慢性阻塞性肺疾病患者周围性多发性神经病（PNP）的患病率增加。这151例COLD患者中有43例（28%）表现出临床明显的PNP，而在32例哮喘患者的对照组中，只有2例临床PNP病例。已知有PNP风险因素的患者未纳入该研究。在此类患者中观察到的多发性神经病通常较轻，主要为感觉性、远端性且以腿部为主。在52例动脉血氧分压（PaO2）高达55托的COLD患者中，21例（40%）出现多发性神经病，而在59例PaO2高于60托的COLD患者中，10例（17%）有多发性神经病。在多因素病因（如预期的那样）中，低氧血症的严重程度（计算为实际PaO2值低于年龄校正后的标称值）以及患者年龄，在统计学上是临床明显PNP的显著预测因素。
