Department of Biological Sciences, Ohio University, 1425 Newark Road, Zanesville, OH 43701, USA.
Am J Trop Med Hyg. 2011 May;84(5):753-6. doi: 10.4269/ajtmh.2011.11-0009.
Onchocerciasis remains an important debilitating disease in many areas of Africa, including Sudan. The status of infection transmission in 2007 was assessed in the vectors of two disease foci in Sudan: Abu Hamed in northern Sudan, which has received at least 10 years of annual treatment and Galabat focus in eastern Sudan, where only minor, largely undocumented treatment activity has occurred. Assessment of more than 30,000 black flies for Onchocerca volvulus infectious stage L3 larvae by using an O-150 polymerase chain reaction protocol showed that black fly infectivity rates were 0.84 (95% confidence interval = 0.0497-1.88) per 10,000 flies for Abu Hamed and 6.9 (95% confidence interval = 1.1-16.4) infective flies per 10,000 for Galabat. These results provide entomologic evidence for suppressed Onchocerca volvulus transmission in the Abu Hamed focus and a moderate transmission rate of the parasite in the Galabat focus.
盘尾丝虫病仍然是非洲许多地区（包括苏丹）一种严重的致残疾病。2007 年，对苏丹两个疾病流行区的媒介物进行了感染传播状况评估：苏丹北部的 Abu Hamed 区已接受了至少 10 年的年度治疗，而在东部的 Galabat 区，只进行了少量治疗活动，且大部分未经记录。利用 O-150 聚合酶链反应方案对超过 30000 只采采蝇进行盘尾丝虫感染期 L3 幼虫检测，结果显示 Abu Hamed 区的采采蝇感染率为每 10000 只 0.84（95%置信区间=0.0497-1.88），Galabat 区为每 10000 只 6.9（95%置信区间=1.1-16.4）感染性采采蝇。这些结果提供了 Abu Hamed 区传播得到抑制的盘尾丝虫病的昆虫学证据，以及 Galabat 区寄生虫中度传播的证据。
