Tan Qinggang, Li Songgang, Ren Jie, Chen Chu
Institute of Nano- and Bio-Polymeric Materials, School of Materials Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, China; E-Mails:
Int J Mol Sci. 2011 Jan 25;12(2):890-904. doi: 10.3390/ijms12020890.
Macroporous scaffolds with controllable pore structure and mechanical properties were fabricated by a porogen fusion technique. Biodegradable material poly (d, l-lactide) (PDLLA) was used as the scaffold matrix. The effects of porogen size, PDLLA concentration and hydroxyapatite (HA) content on the scaffold morphology, porosity and mechanical properties were investigated. High porosity (90% and above) and highly interconnected structures were easily obtained and the pore size could be adjusted by varying the porogen size. With the increasing porogen size and PDLLA concentration, the porosity of scaffolds decreases, while its mechanical properties increase. The introduction of HA greatly increases the impact on pore structure, mechanical properties and water absorption ability of scaffolds, while it has comparatively little influence on its porosity under low HA contents. These results show that by adjusting processing parameters, scaffolds could afford a controllable pore size, exhibit suitable pore structure and high porosity, as well as good mechanical properties, and may serve as an excellent substrate for bone tissue engineering.
通过致孔剂融合技术制备了具有可控孔结构和力学性能的大孔支架。可生物降解材料聚（d，l-丙交酯）（PDLLA）用作支架基质。研究了致孔剂尺寸、PDLLA浓度和羟基磷灰石（HA）含量对支架形态、孔隙率和力学性能的影响。易于获得高孔隙率（90%及以上）和高度互连的结构，并且可以通过改变致孔剂尺寸来调节孔径。随着致孔剂尺寸和PDLLA浓度的增加，支架的孔隙率降低，而其力学性能增加。HA的引入极大地增加了对支架孔结构、力学性能和吸水能力的影响，而在低HA含量下对其孔隙率的影响相对较小。这些结果表明，通过调整加工参数，支架可以提供可控的孔径，展现出合适的孔结构和高孔隙率，以及良好的力学性能，并且可以作为骨组织工程的优良基质。
