Shan Xiaozhong, Zhou Junlai, Ma Tao, Chai Qiongxia
Department of Physical Education and Military Training, Zhejiang University of Technology, Hangzhou, Zhejiang Province 310014, China; E-Mails:
Int J Mol Sci. 2011 Feb 9;12(2):1081-8. doi: 10.3390/ijms12021081.
The purpose of the present study was to investigate the effects of Lycium barbarum polysaccharides (LBP) on exercise-induced oxidative stress in rats. Rats were divided into four groups, i.e., one control group and three LBP treated groups. The animals received an oral administration of physiological saline or LBP (100, 200 and 400 mg/kg body weight) for 28 days. On the day of the exercise test, rats were required to run to exhaustion on the treadmill. Body weight, endurance time, malondialdehyde (MDA), super oxide dismutase (SOD) and glutathione peroxidase (GPX) level of rats were measured. The results showed that the body weight of rats in LBP treated groups were not significantly different from that in the normal control group before and after the experiment (P > 0.05). After exhaustive exercise, the mean endurance time of treadmill running to exhaustion of rats in LBP treated groups were significantly prolonged compared with that in the normal control group. MDA levels of rats in LBP treated groups were significantly decreased compared with that in the normal control group (P < 0.05). SOD and GPX levels of rats in LBP treated groups were significantly increased compared with that in the normal control group (P < 0.05). Together, these results indicate that LBP was effective in preventing oxidative stress after exhaustive exercise.
本研究的目的是探讨枸杞多糖（LBP）对大鼠运动诱导的氧化应激的影响。将大鼠分为四组，即一个对照组和三个LBP处理组。动物口服生理盐水或LBP（100、200和400mg/kg体重），持续28天。在运动测试当天，要求大鼠在跑步机上跑至力竭。测量大鼠的体重、耐力时间、丙二醛（MDA）、超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPX）水平。结果显示，LBP处理组大鼠在实验前后的体重与正常对照组相比无显著差异（P>0.05）。力竭运动后，LBP处理组大鼠跑步机跑至力竭的平均耐力时间与正常对照组相比显著延长。LBP处理组大鼠的MDA水平与正常对照组相比显著降低（P<0.05）。LBP处理组大鼠的SOD和GPX水平与正常对照组相比显著升高（P<0.05）。总之，这些结果表明LBP在预防力竭运动后的氧化应激方面是有效的。
