酒精依赖患者的癫痫样活动及其间接测量的可能性。
Epileptiform activity in alcohol dependent patients and possibilities of its indirect measurement.
机构信息
Center for Neuropsychiatric Research of Traumatic Stress, Department of Psychiatry, First Faculty of Medicine, Charles University, Prague, Czech Republic.
出版信息
PLoS One. 2011 Apr 26;6(4):e18678. doi: 10.1371/journal.pone.0018678.
BACKGROUND
Alcohol dependence during withdrawal and also in abstinent period in many cases is related to reduced inhibitory functions and kindling that may appear in the form of psychosensory symptoms similar to temporal lobe epilepsy frequently in conditions of normal EEG and without seizures. Because temporal lobe epileptic activity tend to spread between hemispheres, it is possible to suppose that measures reflecting interhemispheric information transfer such as electrodermal activity (EDA) might be related to the psychosensory symptoms.
METHODS AND FINDINGS
We have performed measurement of bilateral EDA, psychosensory symptoms (LSCL-33) and alcohol craving (ACQ) in 34 alcohol dependent patients and 32 healthy controls. The results in alcohol dependent patients show that during rest conditions the psychosensory symptoms (LSCL-33) are related to EDA transinformation (PTI) between left and right EDA records (Spearman r = 0.44, p<0.01).
CONCLUSIONS
The result may present potentially useful clinical finding suggesting a possibility to indirectly assess epileptiform changes in alcohol dependent patients.
背景
在戒断期间和戒断后的一段时间内，酒精依赖与抑制功能下降和点燃有关，这可能表现为类似于颞叶癫痫的感觉症状，这种情况在正常脑电图且无癫痫发作的情况下经常出现。由于颞叶癫痫活动倾向于在两个半球之间传播，因此可以假设反映半球间信息传递的措施，如皮肤电活动（EDA），可能与感觉症状有关。
方法和结果
我们对 34 名酒精依赖患者和 32 名健康对照者进行了双侧 EDA、感觉症状（LSCL-33）和酒精渴求（ACQ）的测量。酒精依赖患者的结果表明，在休息状态下，感觉症状（LSCL-33）与左、右 EDA 记录之间的 EDA 传递信息（PTI）呈正相关（Spearman r=0.44，p<0.01）。
结论
这一结果可能提供了有用的临床发现，提示有可能间接评估酒精依赖患者的癫痫样变化。
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