Institute for Virus Research, Kyoto University, Shogoin-Kawahara, Sakyo-ku, Kyoto 606-8507, Japan.
Mol Neurobiol. 2011 Aug;44(1):7-12. doi: 10.1007/s12035-011-8186-0. Epub 2011 May 4.
Neurogenesis occurs throughout adulthood in the mammalian brain. Newly born neurons are incorporated into the functional networks of both the olfactory bulb and the hippocampal dentate gyrus, and there is growing evidence that adult neurogenesis is important for various brain functions. Continuous neurogenesis is achieved by the coordinated proliferation and differentiation of adult neural stem cells. In this review, we discuss the recent findings concerning the roles of Notch signaling in adult neural stem cells.
神经发生发生在哺乳动物大脑的整个成年期。新产生的神经元整合到嗅球和海马齿状回的功能网络中，越来越多的证据表明成年神经发生对于各种大脑功能很重要。通过成年神经干细胞的协调增殖和分化来实现连续的神经发生。在这篇综述中，我们讨论了 Notch 信号在成年神经干细胞中的作用的最新发现。
