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真菌性主动脉和髂动脉瘤的手术治疗结果。

Surgical outcome for mycotic aortic and iliac anuerysm.

机构信息

Division of Thoracic & Cardiovascular Surgery, Chang Gung Memorial Hospital, Chang Gung University, 5, Fushing Street, Gueishan Shiang, Taoyuan, 333, Taiwan, Republic of China.

出版信息

World J Surg. 2011 Jul;35(7):1671-8. doi: 10.1007/s00268-011-1104-9.

Abstract

BACKGROUND

The present study was designed to review surgical outcomes for mycotic aneurysm of the aortic or iliac arteries at a single center.

METHODS

The study was based on retrospective chart review of patients undergoing operation for mycotic aneurysm.

RESULTS

From January 1998 to December 2007, 56 patients received surgical treatment for mycotic aneurysm of the aortic or iliac arteries. Aneurysm sites included the aortic arch (n=5), proximal thoracic aorta (n=4), distal thoracic aorta (n=5), paravisceral aorta (n=5), juxtarenal aorta (n=4), infrarenal aorta (n=30), and iliac arteries (n=3). Salmonella was the leading pathogen (n=34). Nineteen patients with suprarenal lesions underwent in situ prosthetic graft replacement (n=17), extra-anatomic bypass (n=1), or endovascular aneurysm repair (EVAR) (n=1), and 37 patients with infrarenal lesions underwent the same procedures (n=16, 20, and 1, respectively). Overall in-hospital mortality was 23%. After discharge, four patients (7%) developed reinfection that led to fatal sepsis. Graft infection developed after three in situ prosthetic grafts (9%) and one extra-anatomic bypass (5%). Patients with suprarenal aortic lesions had poorer in-hospital (34%) and late (16%) mortality rates than those with infrarenal lesions (p=0.025). Those with suprarenal lesions also had a lower cumulative survival rate (p=0.016).

CONCLUSIONS

The location of mycotic aneurysm was the determinant of mortality. Mycotic aneurysm of the suprarenal aorta has poor prognosis and requires alternative surgical treatment.

摘要

背景

本研究旨在回顾单一中心主动脉或髂动脉真菌性动脉瘤的手术治疗结果。

方法

本研究基于对接受手术治疗的真菌性动脉瘤患者的回顾性病历分析。

结果

1998 年 1 月至 2007 年 12 月,56 例主动脉或髂动脉真菌性动脉瘤患者接受了手术治疗。动脉瘤部位包括主动脉弓(n=5)、升主动脉近端(n=4)、降主动脉远段(n=5)、内脏动脉旁(n=5)、肾动脉以上主动脉(n=4)、肾下主动脉(n=30)和髂动脉(n=3)。沙门氏菌是主要病原体(n=34)。19 例肾上病变患者行原位假体移植物置换(n=17)、体外旁路(n=1)或血管内动脉瘤修复(EVAR)(n=1),37 例肾下病变患者行相同治疗(n=16、20 和 1)。总的院内死亡率为 23%。出院后,4 例(7%)患者出现再感染,导致致命性败血症。3 例原位假体移植物(9%)和 1 例体外旁路(5%)后发生移植物感染。肾上主动脉病变患者的院内(34%)和晚期(16%)死亡率均高于肾下病变患者(p=0.025)。肾上病变患者的累积生存率也较低(p=0.016)。

结论

真菌性动脉瘤的位置是决定死亡率的因素。肾上真菌性动脉瘤预后差,需要替代手术治疗。

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