Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, Tennessee 37203-1738, USA.
Nutr Cancer. 2011;63(4):538-48. doi: 10.1080/01635581.2011.539316.
We assessed weight change from diagnosis to approximately 18 mo after cancer diagnosis and evaluated its correlates in a large, population-based, cohort study of women diagnosed with stage 0-IV breast cancer. A total of 4,561 cases with weight information 1 yr prior to diagnosis, at diagnosis, and at the 18-mo postdiagnosis interview were included in the study. Multinomial logistic regression models were conducted to examine the association of weight change from diagnosis to 18 mo after diagnosis with sociodemographic, clinical, and lifestyle factors. The mean weight change from diagnosis to 18 mo after diagnosis was a gain of 1.7 kg (median: 2.0). Overall, 61% of women gained weight, 27% gained 2-5 kg, and 24% gained ≥5 kg, while approximately 14% lost >2 kg during the 18-mo postdiagnosis period. Greater weight gain was significantly related to younger age, premenopausal status, mixed receptor status, more advanced disease stage, prediagnosis weight loss, higher dietary intake, and cigarette smoking. Women with obesity and serious comorbidity were more likely to lose weight. Moderate exercise was not significantly related to weight change. Weight gain is common among breast cancer survivors. Sociodemographic, clinical, and lifestyle factors are related to weight change. Appropriate intervention strategies should be developed.
我们评估了从诊断到癌症诊断后约 18 个月的体重变化，并在一项针对 0 期-IV 期乳腺癌女性的大型基于人群的队列研究中评估了其相关性。共有 4561 例病例在诊断前 1 年、诊断时和诊断后 18 个月的访谈中有体重信息，包括在研究中。使用多项逻辑回归模型来检查从诊断到诊断后 18 个月体重变化与社会人口统计学、临床和生活方式因素的关联。从诊断到诊断后 18 个月的体重平均变化为增加 1.7 公斤（中位数：2.0）。总体而言，61%的女性体重增加，27%增加 2-5 公斤，24%增加≥5 公斤，而约 14%在诊断后 18 个月期间体重减轻>2 公斤。体重增加较多与年龄较小、绝经前状态、混合受体状态、疾病分期较晚、诊断前体重减轻、较高的饮食摄入和吸烟有关。肥胖和严重合并症的女性更有可能减重。适度运动与体重变化无显著相关性。体重增加在乳腺癌幸存者中很常见。社会人口统计学、临床和生活方式因素与体重变化有关。应制定适当的干预策略。
