Shanghai Institute of Preventive Medicine, 1380 Zhong Shan Road (W), 200336 Shanghai, China.
Cancer Causes Control. 2010 Apr;21(4):621-9. doi: 10.1007/s10552-009-9491-z. Epub 2009 Dec 31.
In a population-based cohort study of 5,014 women with stage 0-III breast cancer, we evaluated weight change patterns from diagnosis to 6, 18, and 36 months post-diagnosis. Patients were recruited to the study approximately 6 months after cancer diagnosis between 2002 and 2006 and followed through 36 months post-diagnosis. The medians of weight change from diagnosis to 6, 18, and 36 months post-diagnosis were 1.0, 2.0, and 1.0 kg, respectively. Approximately, 26% of survivors gained > or =5% of their at-diagnosis body weight during the first 6 months after diagnosis, while 37% and 33% of women gained the same percentage of weight at 18 and 36 months post-diagnosis. More weight gain was observed among women who had a more advanced disease stage, were younger, had lower body mass index at diagnosis, were premenopausal, or received chemotherapy or radiotherapy during the first 6 months after cancer diagnosis. Multivariate analyses indicated that age at diagnosis, body size, comorbidity, and disease stage independently predicted weight gain from diagnosis to 36 months post-diagnosis. In summary, weight gain is common over the first 3 years after breast cancer diagnosis among Chinese women. More research is needed to investigate measures to prevent weight gain in breast cancer survivors.
在一项针对 5014 名患有 0-III 期乳腺癌的女性的基于人群的队列研究中，我们评估了从诊断到诊断后 6、18 和 36 个月的体重变化模式。大约在诊断后 6 个月至 2002 年至 2006 年之间招募患者参加该研究，并随访至诊断后 36 个月。从诊断到诊断后 6、18 和 36 个月的体重变化中位数分别为 1.0、2.0 和 1.0 公斤。大约 26%的幸存者在诊断后 6 个月内体重增加了等于或大于其诊断时体重的 5%，而 37%和 33%的女性在诊断后 18 和 36 个月时体重增加了相同的百分比。在疾病晚期、年龄较小、诊断时体重指数较低、绝经前或在癌症诊断后 6 个月内接受化疗或放疗的女性中，体重增加更多。多变量分析表明，诊断时的年龄、体型、合并症和疾病分期独立预测了从诊断到诊断后 36 个月的体重增加。总之，在中国女性中，乳腺癌诊断后 3 年内体重增加很常见。需要进一步研究以探讨预防乳腺癌幸存者体重增加的措施。
