Bone and Musculoskeletal Research Programme, University of Aberdeen, Foresterhill, Aberdeen, Scotland.
J Bone Miner Res. 2011 May;26(5):941-7. doi: 10.1002/jbmr.285.
Flavonoids are bioactive polyphenols found particularly in fruit and vegetables, but little is known about their role in bone health in humans. The aim of this observational study was to investigate whether dietary flavonoid intake was associated with bone mineral density (BMD) and bone resorption in a large group of perimenopausal Scottish women. Over 3000 women completed a food frequency questionnaire as part of an osteoporosis screening study. The diets were analyzed for flavonoid intake using a food composition database. BMD was measured at the femoral neck (FN) and lumbar spine (LS) by dual-energy X-ray absorptiometry (DXA). Free pyridinoline (PYD) and deoxypyridinoline (DPD) were measured by high-performance liquid chromatography (HPLC) in second early morning fasted urine samples. The mean flavonoid intake of the diet was 307 ±199 mg/d. The catechin family contributed the most to flavonoid intakes (55%), and the flavones the least (<1%). Associations were found between energy-adjusted total flavonoid intakes and BMD at the FN and LS (FN r = 0.054, LS r = 0.036, p ≤ .05). Annual percent change in BMD was associated with intakes of procyanidins and catechins (p ≤ .05), and flavanones were negatively associated with bone-resorption markers (PYD r = -0.049, DPD r = -0.057, p ≤ .001). These associations were still seen after adjusting for confounders. It is concluded that dietary flavonoid intakes are associated with BMD, supporting the evidence from animal and cellular studies.
类黄酮是一种生物活性多酚，主要存在于水果和蔬菜中，但人们对其在人类骨骼健康中的作用知之甚少。本观察性研究旨在调查在一大群苏格兰围绝经期妇女中，饮食类黄酮摄入量是否与骨密度（BMD）和骨吸收有关。超过 3000 名女性完成了作为骨质疏松症筛查研究的一部分的食物频率问卷。使用食物成分数据库分析饮食中的类黄酮摄入量。通过双能 X 射线吸收法（DXA）测量股骨颈（FN）和腰椎（LS）的 BMD。通过高效液相色谱法（HPLC）在第二次清晨空腹尿液样本中测量游离吡啶啉（PYD）和脱氧吡啶啉（DPD）。饮食中类黄酮的平均摄入量为 307±199mg/d。儿茶素家族对类黄酮的摄入量贡献最大（55%），而类黄酮的摄入量最少（<1%）。在 FN 和 LS 处，能量调整后的总类黄酮摄入量与 BMD 之间存在相关性（FN r=0.054，LS r=0.036，p≤0.05）。BMD 的年百分变化与原花青素和儿茶素的摄入量相关（p≤0.05），而黄烷酮与骨吸收标志物呈负相关（PYD r=-0.049，DPD r=-0.057，p≤0.001）。调整混杂因素后仍可见到这些相关性。结论是，饮食类黄酮摄入量与 BMD 相关，支持了来自动物和细胞研究的证据。
