Vanin A F, Chazov E I
Biofizika. 2011 Mar-Apr;56(2):304-15.
A stable hypotensive preparation (Oxacom) based on dinitrosyl iron complexes (DNIC) with glutathione has been developed. The preparation has successfully passed through pharmacological trials. The tests on volunteers have shown a high hypotensive activity of the preparation: a single intravenous infusion of its aqueous solution at a dose of 0.2 microM per kg of body weight led to a 20-30% decrease in arterial pressure, which persisted for a period of 15-20 h. Similar experiments on the animals demonstrated that aqueous solutions of DNIC with cysteine or glutathione exert also the hypotensive action due to their vasodilatory activity. Besides, these complexes accelerate wound healing and produce a potent erective action. There is reason to suggest that DNIC with thiol-containing ligands as NO donors can produce the cytotoxic action on the pathogenic mycobacteria Mycobacterium tuberculosis and, after respective treatment, inhibit cancer cell proliferation. These complexes can be used as analgetics, for inhibiting the adhesion process, in the therapy of preexplampsia, spermatogenesis pathologies, and in cosmetology for the treatment of skin injury.
一种基于二亚硝酰基铁配合物（DNIC）与谷胱甘肽的稳定降压制剂（Oxacom）已被研发出来。该制剂已成功通过药理学试验。对志愿者的测试表明该制剂具有很高的降压活性：以每千克体重0.2微摩尔的剂量单次静脉输注其水溶液会导致动脉血压下降20% - 30%，且这种降压效果持续15 - 20小时。在动物身上进行的类似实验表明，含有半胱氨酸或谷胱甘肽的DNIC水溶液由于其血管舒张活性也具有降压作用。此外，这些配合物能加速伤口愈合并产生强烈的勃起作用。有理由认为，含硫醇配体的DNIC作为一氧化氮供体可对致病性分枝杆菌结核分枝杆菌产生细胞毒性作用，并在经过相应治疗后抑制癌细胞增殖。这些配合物可用作镇痛药，用于抑制黏附过程，治疗先兆子痫、精子发生病理状况，还可用于美容领域治疗皮肤损伤。
