近红外光响应核壳纳米胶束用于靶向药物递送。
Near-infrared light-responsive core-shell nanogels for targeted drug delivery.
机构信息
Center For Research at the Bio/nano Interface, Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, United States.
出版信息
ACS Nano. 2011 Jun 28;5(6):5094-9. doi: 10.1021/nn201171r. Epub 2011 May 17.
Abstract
A near-infrared light-responsive drug delivery platform based on Au-Ag nanorods (Au-Ag NRs) coated with DNA cross-linked polymeric shells was constructed. DNA complementarity has been applied to develop a polyacrylamide-based sol-gel transition system to encapsulate anticancer drugs into the gel scaffold. The Au-Ag NR-based nanogels can also be readily functionalized with targeting moieties, such as aptamers, for specific recognition of tumor cells. When exposed to NIR irradiation, the photothermal effect of the Au-Ag NRs leads to a rapid rise in the temperature of the surrounding gel, resulting in the fast release of the encapsulated payload with high controllability. In vitro study confirmed that aptamer-functionalized nanogels can be used as drug carriers for targeted drug delivery with remote control capability by NIR light with high spatial/temporal resolution.
摘要
构建了一种基于金-银纳米棒（Au-Ag NRs）的近红外光响应药物传递平台，该纳米棒表面覆盖有 DNA 交联聚合物壳。DNA 互补性被应用于开发一种基于聚丙烯酰胺的溶胶-凝胶转变体系，将抗癌药物封装到凝胶支架中。基于 Au-Ag NR 的纳米凝胶还可以很容易地功能化靶向部分，如适体，以特异性识别肿瘤细胞。当暴露于近红外光照射时，Au-Ag NRs 的光热效应导致周围凝胶温度迅速升高，从而实现了封装的有效载荷的快速释放，具有高度的可控性。体外研究证实，适体功能化纳米凝胶可用作药物载体，通过具有高时空分辨率的近红外光进行远程控制的靶向药物传递。
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