Moan Johan, Lagunova Zoya, Bruland Oyvind, Juzeniene Asta
Department of Radiation Biology; The Norwegian Radium Hospital; Oslo, Norway.
Dermatoendocrinol. 2010 Apr;2(2):55-7. doi: 10.4161/derm.2.2.12664.
The overall death rates are highest in the winter season in many countries at high latitudes. In some but not all countries, this is also true for more specific diseases such as cancer, cardiovascular diseases and influenza. For internal cancers we find no consistent, significant seasonal variation, neither of incidence nor of death rates. On the other hand, we find a significant seasonal variation of cancer prognosis with season of diagnosis in Norway. Best prognosis is found for summer and autumn diagnosis; i.e., for the seasons of the best status of vitamin D in the population. There were no corresponding seasonal variations, neither of the rates of diagnosis, nor of the rates of death which could explain the variations of prognosis. The most likely reason for this variation is that the vitamin D status in Norway is significantly better in summer and autumn than in winter and spring. Earlier, seasonal variations have been explained by circannual variations of certain hormones, but the data are not consistent.
在许多高纬度国家，冬季的总体死亡率最高。在一些（但并非所有）国家，对于某些特定疾病，如癌症、心血管疾病和流感，情况也是如此。对于内部癌症，我们没有发现发病率或死亡率存在一致的、显著的季节性变化。另一方面，我们发现挪威癌症预后随诊断季节存在显著的季节性变化。夏季和秋季诊断的预后最佳；也就是说，是在人群中维生素D状态最佳的季节。在诊断率和死亡率方面均没有相应的季节性变化能够解释预后的差异。这种差异最可能的原因是挪威夏季和秋季的维生素D状态明显优于冬季和春季。此前，季节性变化曾被某些激素的年度周期性变化所解释，但数据并不一致。
