Lagunova Zoya, Porojnicu Alina Carmen, Dahlback Arne, Berg Jens Petter, Beer Tomasz M, Moan Johan
Department of Radiation Biology, Institute for Cancer Research, Montebello, Oslo, Norway.
Prostate. 2007 Sep 1;67(12):1362-70. doi: 10.1002/pros.20577.
We have earlier found that the prognosis for several cancers is dependent on season of diagnosis. More recently, both prostate cancer incidence and mortality have been shown to increase with increasing latitude, which probably relates to photosynthesis of vitamin D.
The 3 year survival of prostate cancer patients has been analyzed with the Cox regression method for two age groups at different latitudes in Norway.
Patients diagnosed during the summer and autumn had the best prognosis (Ralative risk (RR) death 0.8; 95% CI 0.75-0.85). Similar results were observed in three regions of the country that differ with respect to annual fluences of solar UV radiation, incidence rates of squamous cell carcinoma (SCC) and intake of fish. Furthermore, similar relationship between the season and survival was seen among patients </=65 years and >65 years old, although the younger group had a slightly larger advantage of summer and autumn diagnosis.
The seasonal effect on prognosis may be related to the seasonal variations of calcidiol (the marker of vitamin D status). The lack of latitude effect and the similarity of prognosis for different age groups may be related to higher consumption of vitamin D in food in the north region and to increase of such consumption with age.
我们之前发现几种癌症的预后取决于诊断季节。最近，前列腺癌的发病率和死亡率均已显示会随着纬度的增加而上升，这可能与维生素D的光合作用有关。
采用Cox回归方法分析了挪威不同纬度两个年龄组前列腺癌患者的3年生存率。
在夏季和秋季被诊断出的患者预后最佳（死亡相对风险（RR）为0.8；95%置信区间为0.75 - 0.85）。在该国三个因太阳紫外线年通量、鳞状细胞癌（SCC）发病率和鱼类摄入量不同的地区也观察到了类似结果。此外，在年龄≤65岁和＞65岁的患者中也观察到了季节与生存率之间的类似关系，尽管较年轻组在夏季和秋季诊断时具有稍大的优势。
对预后的季节效应可能与骨化二醇（维生素D状态的标志物）的季节变化有关。缺乏纬度效应以及不同年龄组预后的相似性可能与北部地区食物中维生素D的较高摄入量以及随着年龄增长这种摄入量的增加有关。
