• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

雄激素和 Let-7d 对前列腺癌细胞 PBX3 表达的调控。

Regulation of PBX3 expression by androgen and Let-7d in prostate cancer.

机构信息

Faculty Division Aker University Hospital, University of Oslo, Aker, N-0514 Oslo, Norway.

出版信息

Mol Cancer. 2011 May 6;10:50. doi: 10.1186/1476-4598-10-50.

DOI:10.1186/1476-4598-10-50
PMID:21548940
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3112428/
Abstract

BACKGROUND

The pre-leukemia transcription factor 3 (PBX) is part of the PBX family of transcription factors, which is known to regulate genes involved in differentiation of urogenital organs and steroidogenesis. This is of interest with regard to prostate cancer progression as regulation of steroidogenesis is one of the mechanisms involved in the development of castration-resistant prostate cancer. In light of this we wanted to investigate the possible involvement of androgen regulation of PBX3 expression in prostate cancer.

RESULTS

In this study, we show that PBX3 is post-transcriptionally regulated by androgen in prostate cancer cells and that the effect might be independent of the androgen receptor. Furthermore, PBX3 was identified as a target of Let-7d, an androgen regulated microRNA. Let-7d was down-regulated in malignant compared to benign prostate tissue, whereas up-regulation of PBX3 expression was observed.

CONCLUSIONS

We demonstrate that PBX3 is up-regulated in prostate cancer and post- transcriptionally regulated by androgen through Let-7d.

摘要

背景

白血病前转录因子 3（PBX）是转录因子 PBX 家族的一部分，已知其可调节参与尿生殖器官分化和类固醇生成的基因。这与前列腺癌的进展有关，因为类固醇生成的调节是导致去势抵抗性前列腺癌发生的机制之一。有鉴于此，我们希望研究雄激素对 PBX3 表达的调节是否参与前列腺癌的发生。

结果

在这项研究中，我们表明雄激素可通过转录后调控前列腺癌细胞中的 PBX3，并且这种作用可能独立于雄激素受体。此外，PBX3 被鉴定为雄激素调节的 microRNA Let-7d 的靶标。Let-7d 在恶性前列腺组织中相对于良性前列腺组织下调，而 PBX3 表达上调。

结论

我们证明 PBX3 在前列腺癌中上调，并通过 Let-7d 被雄激素转录后调控。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe2a/3112428/9402ca3201c4/1476-4598-10-50-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe2a/3112428/f823f27fd74e/1476-4598-10-50-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe2a/3112428/03ecda059ded/1476-4598-10-50-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe2a/3112428/43943d8c4dee/1476-4598-10-50-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe2a/3112428/e1a36f92adc0/1476-4598-10-50-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe2a/3112428/9e90d5110265/1476-4598-10-50-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe2a/3112428/9402ca3201c4/1476-4598-10-50-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe2a/3112428/f823f27fd74e/1476-4598-10-50-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe2a/3112428/03ecda059ded/1476-4598-10-50-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe2a/3112428/43943d8c4dee/1476-4598-10-50-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe2a/3112428/e1a36f92adc0/1476-4598-10-50-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe2a/3112428/9e90d5110265/1476-4598-10-50-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe2a/3112428/9402ca3201c4/1476-4598-10-50-6.jpg

相似文献

1
Regulation of PBX3 expression by androgen and Let-7d in prostate cancer.雄激素和 Let-7d 对前列腺癌细胞 PBX3 表达的调控。
Mol Cancer. 2011 May 6;10:50. doi: 10.1186/1476-4598-10-50.
2
PBX3 is a putative biomarker of aggressive prostate cancer.PBX3是侵袭性前列腺癌的一种潜在生物标志物。
Int J Cancer. 2016 Oct 15;139(8):1810-20. doi: 10.1002/ijc.30220. Epub 2016 Jun 25.
3
LncRNA HOXA-AS2 promotes the progression of prostate cancer via targeting miR-509-3p/PBX3 axis.长链非编码 RNA HOXA-AS2 通过靶向 miR-509-3p/PBX3 轴促进前列腺癌的进展。
Biosci Rep. 2020 Aug 28;40(8). doi: 10.1042/BSR20193287.
4
Let-7c functions as a metastasis suppressor by targeting MMP11 and PBX3 in colorectal cancer.Let-7c 通过靶向结直肠癌中的 MMP11 和 PBX3 发挥转移抑制作用。
J Pathol. 2012 Feb;226(3):544-55. doi: 10.1002/path.3014. Epub 2011 Dec 5.
5
RhoA as a mediator of clinically relevant androgen action in prostate cancer cells.RhoA作为前列腺癌细胞中临床相关雄激素作用的介质。
Mol Endocrinol. 2012 May;26(5):716-35. doi: 10.1210/me.2011-1130. Epub 2012 Mar 28.
6
PBX3/MEK/ERK1/2/LIN28/let-7b positive feedback loop enhances mesenchymal phenotype to promote glioblastoma migration and invasion. PBX3/MEK/ERK1/2/LIN28/let-7b 正反馈环增强间充质表型以促进神经胶质瘤迁移和侵袭。
J Exp Clin Cancer Res. 2018 Jul 17;37(1):158. doi: 10.1186/s13046-018-0841-0.
7
Retinoic acid regulates the expression of PBX1, PBX2, and PBX3 in P19 cells both transcriptionally and post-translationally.视黄酸在转录和翻译后水平上调节P19细胞中PBX1、PBX2和PBX3的表达。
J Cell Biochem. 2004 May 1;92(1):147-63. doi: 10.1002/jcb.20057.
8
The transcription factor PBX3 promotes tumor cell growth through transcriptional suppression of the tumor suppressor p53.转录因子 PBX3 通过转录抑制肿瘤抑制因子 p53 促进肿瘤细胞生长。
Acta Pharmacol Sin. 2021 Nov;42(11):1888-1899. doi: 10.1038/s41401-020-00599-9. Epub 2021 Feb 1.
9
PLZF regulates Pbx1 transcription and Pbx1-HoxC8 complex leads to androgen-independent prostate cancer proliferation.早幼粒细胞白血病锌指蛋白调控前B细胞白血病转录因子1的转录，且前B细胞白血病转录因子1-同源盒基因C8复合物导致雄激素非依赖性前列腺癌增殖。
Prostate. 2006 Jul 1;66(10):1092-9. doi: 10.1002/pros.20443.
10
Androgen receptor as a regulator of ZEB2 expression and its implications in epithelial-to-mesenchymal transition in prostate cancer.雄激素受体作为 ZEB2 表达的调节剂及其在前列腺癌上皮间质转化中的意义。
Endocr Relat Cancer. 2014 May 8;21(3):473-86. doi: 10.1530/ERC-13-0514. Print 2014 Jun.

引用本文的文献

1
PBX3-HMGCR Axis Promotes Hepatocellular Carcinoma Progression Through Enhancing De Novo Cholesterol Biosynthesis.PBX3-HMGCR轴通过增强从头胆固醇生物合成促进肝细胞癌进展。
Int J Mol Sci. 2025 May 29;26(11):5210. doi: 10.3390/ijms26115210.
2
Non-cutaneous syncytial myoepitheliomas are identical to cutaneous counterparts: a clinicopathologic study of 24 tumors occurring at diverse locations.非皮肤性合胞体肌上皮瘤与皮肤性肿瘤一致：24 例不同部位发生的肿瘤的临床病理研究。
Virchows Arch. 2023 Nov;483(5):665-675. doi: 10.1007/s00428-023-03609-3. Epub 2023 Aug 7.
3
Metabolic pathways of potential miRNA biomarkers derived from liquid biopsy in epithelial ovarian cancer.

本文引用的文献

1
MicroRNA let-7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2.miRNA let-7a 通过靶向 E2F2 和 CCND2 抑制人前列腺癌细胞的体外和体内增殖。
PLoS One. 2010 Apr 14;5(4):e10147. doi: 10.1371/journal.pone.0010147.
2
Targeting HOX and PBX transcription factors in ovarian cancer.靶向卵巢癌细胞中的 HOX 和 PBX 转录因子。
BMC Cancer. 2010 Mar 10;10:89. doi: 10.1186/1471-2407-10-89.
3
The role of let-7 in cell differentiation and cancer.Let-7 在细胞分化和癌症中的作用。
上皮性卵巢癌液体活检中潜在miRNA生物标志物的代谢途径
Oncol Lett. 2023 Feb 23;25(4):142. doi: 10.3892/ol.2023.13728. eCollection 2023 Apr.
4
Potential Molecular Mechanisms of Recurrent and Progressive Meningiomas: A Review of the Latest Literature.复发性和进展性脑膜瘤的潜在分子机制：最新文献综述
Front Oncol. 2022 May 30;12:850463. doi: 10.3389/fonc.2022.850463. eCollection 2022.
5
EIF4A3-induced circTOLLIP promotes the progression of hepatocellular carcinoma via the miR-516a-5p/PBX3/EMT pathway.EIF4A3 诱导的 circTOLLIP 通过 miR-516a-5p/PBX3/EMT 通路促进肝癌的进展。
J Exp Clin Cancer Res. 2022 May 5;41(1):164. doi: 10.1186/s13046-022-02378-2.
6
Dysregulation of the miRNome unveils a crosstalk between obesity and prostate cancer: miR-107 asa personalized diagnostic and therapeutic tool.微小RNA组失调揭示肥胖与前列腺癌之间的相互作用：miR-107作为个性化诊断和治疗工具
Mol Ther Nucleic Acids. 2022 Feb 12;27:1164-1178. doi: 10.1016/j.omtn.2022.02.010. eCollection 2022 Mar 8.
7
Downregulated let-7d positively stimulates rectum adenocarcinoma cell malignant biological behaviors by upregulating ATP binding cassette subfamily C member 2.下调的let-7d通过上调ATP结合盒亚家族C成员2来正向刺激直肠腺癌细胞的恶性生物学行为。
Transl Cancer Res. 2019 Aug;8(4):1540-1549. doi: 10.21037/tcr.2019.08.04.
8
The regulation of PBXs and their emerging role in cancer. PBXs 的调控及其在癌症中的新作用。
J Cell Mol Med. 2022 Mar;26(5):1363-1379. doi: 10.1111/jcmm.17196. Epub 2022 Jan 23.
9
Roles of Key Epigenetic Regulators in the Gene Transcription and Progression of Prostate Cancer.关键表观遗传调节因子在前列腺癌基因转录和进展中的作用
Front Mol Biosci. 2021 Dec 15;8:743376. doi: 10.3389/fmolb.2021.743376. eCollection 2021.
10
Androgen Receptor-Related Non-coding RNAs in Prostate Cancer.前列腺癌中与雄激素受体相关的非编码RNA
Front Cell Dev Biol. 2021 Apr 1;9:660853. doi: 10.3389/fcell.2021.660853. eCollection 2021.
Endocr Relat Cancer. 2010 Jan 29;17(1):F19-36. doi: 10.1677/ERC-09-0184. Print 2010 Mar.
4
MicroRNAs and prostate cancer.微小 RNA 与前列腺癌。
Endocr Relat Cancer. 2010 Jan 29;17(1):F1-17. doi: 10.1677/ERC-09-0172. Print 2010 Mar.
5
miR-21: an androgen receptor-regulated microRNA that promotes hormone-dependent and hormone-independent prostate cancer growth.微小RNA-21：一种受雄激素受体调控的微小RNA，可促进激素依赖性和激素非依赖性前列腺癌的生长。
Cancer Res. 2009 Sep 15;69(18):7165-9. doi: 10.1158/0008-5472.CAN-09-1448. Epub 2009 Sep 8.
6
Inhibition of cancer cell proliferation by designed peptide amphiphiles.设计的肽两亲分子对癌细胞增殖的抑制作用。
Acta Biomater. 2009 Mar;5(3):842-53. doi: 10.1016/j.actbio.2008.11.002. Epub 2008 Nov 27.
7
HOX transcription factors are potential therapeutic targets in non-small-cell lung cancer (targeting HOX genes in lung cancer).HOX转录因子是非小细胞肺癌潜在的治疗靶点（针对肺癌中的HOX基因）。
Br J Cancer. 2009 Feb 10;100(3):470-5. doi: 10.1038/sj.bjc.6604857. Epub 2009 Jan 20.
8
MicroRNA profile analysis of human prostate cancers.人类前列腺癌的微小RNA谱分析
Cancer Gene Ther. 2009 Mar;16(3):206-16. doi: 10.1038/cgt.2008.77. Epub 2008 Oct 24.
9
Disrupting the interaction between HOX and PBX causes necrotic and apoptotic cell death in the renal cancer lines CaKi-2 and 769-P.破坏HOX与PBX之间的相互作用会导致肾癌CaKi-2和769-P细胞系发生坏死性和凋亡性细胞死亡。
J Urol. 2008 Nov;180(5):2196-201. doi: 10.1016/j.juro.2008.07.018. Epub 2008 Sep 20.
10
Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer.微小RNA和信使RNA的基因组分析揭示了前列腺癌中微小RNA表达失调的情况。
Cancer Res. 2008 Aug 1;68(15):6162-70. doi: 10.1158/0008-5472.CAN-08-0144.