Instituto de Oftalmología Fundación Conde de Valenciana, Chimalpopoca 14 Colonia Obrera, CP 06800 DF, México.
BMC Pregnancy Childbirth. 2011 May 6;11:33. doi: 10.1186/1471-2393-11-33.
Pregnancy is accompanied by several hemodynamic, biochemical and hematological changes which revert to normal values after labor. The mean values of these parameters have been reported for developed countries, but not for Mexican women. Furthermore, labor constitutes a stress situation, in which these factors may be altered. It is known that serologic increase of heat shock protein (Hsp) 70 is associated with abnormal pregnancies, presenting very low level in normal pregnant women. Nevertheless, there are no studies where these measurements are compared in healthy pregnant women at their third trimester of pregnancy (3TP) and the active labor phase (ActLP).
Seventy five healthy Mexican pregnant women were included. Hemodynamic, biochemical and hematological parameters were obtained in all cases, and serum Hsp70 levels were measured in a sample of 15 women at 3TP and at ActLP.
Significant differences were found in most analysis performed and in Hsp70 concentration at 3TP as compared to ActLP, however all were within normal range in both conditions, supporting that only in pathological pregnancies Hsp70 is drastically increased.
Results obtained indicate that 3TP and ActLP have clinical similarities in normal pregnancies, therefore if abnormalities are found during 3TP, precautions should be taken before ActLP.
妊娠伴随着多种血液动力学、生化和血液学变化，这些变化在分娩后恢复正常。这些参数的平均值已在发达国家报道，但尚未在墨西哥女性中报道。此外，分娩是一种应激状态，这些因素可能会发生变化。已知热休克蛋白（Hsp）70 的血清学增加与异常妊娠有关，在正常孕妇中水平非常低。然而，目前还没有研究比较这些测量值在健康孕妇的第三个孕期（3TP）和活跃分娩期（ActLP）之间的差异。
共纳入 75 名健康的墨西哥孕妇。所有患者均获得血液动力学、生化和血液学参数，并在 15 名孕妇的样本中测量血清 Hsp70 水平，分别在 3TP 和 ActLP 时进行测量。
与 ActLP 相比，3TP 时进行的大多数分析和 Hsp70 浓度均存在显著差异，但在两种情况下均在正常范围内，表明只有在病理性妊娠中 Hsp70 才会大幅增加。
研究结果表明，在正常妊娠中，3TP 和 ActLP 在临床方面具有相似性，因此如果在 3TP 期间发现异常，应在 ActLP 之前采取预防措施。
