昼夜节律：生物时钟以磷酸时间工作。
Circadian rhythms: biological clocks work in phospho-time.
机构信息
Washington University Medical School, Saint Louis, MO 63110, USA.
出版信息
Curr Biol. 2011 May 10;21(9):R305-7. doi: 10.1016/j.cub.2011.04.005.
PMID:21549947
Abstract
The 24 hour molecular oscillator requires precisely calibrated degradation of core clock proteins, like PERIOD. New studies shed light on a sequential series of PERIOD phosphorylation events that first inhibits, then accelerates PERIOD degradation.
摘要
24 小时分子振荡器需要精确校准核心时钟蛋白（如 PERIOD）的降解。新的研究揭示了一系列顺序发生的 PERIOD 磷酸化事件，这些事件首先抑制，然后加速 PERIOD 的降解。
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