Washington University Medical School, Saint Louis, MO 63110, USA.
Curr Biol. 2011 May 10;21(9):R305-7. doi: 10.1016/j.cub.2011.04.005.
The 24 hour molecular oscillator requires precisely calibrated degradation of core clock proteins, like PERIOD. New studies shed light on a sequential series of PERIOD phosphorylation events that first inhibits, then accelerates PERIOD degradation.
24 小时分子振荡器需要精确校准核心时钟蛋白（如 PERIOD）的降解。新的研究揭示了一系列顺序发生的 PERIOD 磷酸化事件，这些事件首先抑制，然后加速 PERIOD 的降解。
