Functional Genomics and Gene Silencing Group, Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, 500007, India.
Centre for Chemical Biology, Indian Institute of Chemical Technology, Uppal Roadm, Hyderabad, 500007, India.
Mol Neurobiol. 2018 Apr;55(4):3564-3576. doi: 10.1007/s12035-017-0573-8. Epub 2017 May 17.
Circadian rhythm which governs basic physiological activities like sleeping, feeding and energy consumption is regulated by light-controlled central clock genes in the pacemaker neuron. The timekeeping machinery with unique transcriptional and post-transcriptional feedback loops is controlled by different small regulatory RNAs in the brain. Roles of the multiple neuronal genes, especially post-transcriptional regulation, splicing, polyadenylation, mature mRNA editing, and stability of translation products, are controlled by epigenetic activities orchestrated via small RNAs. Collectively, these mechanisms regulate clock and light-controlled genes for effecting pacemaker activity and entrainment. Regulatory small RNAs of the circadian circuit, timekeeping mechanism, synchronization of regular entrainment, oscillation, and rhythmicity are regulated by diversified RNA molecules. Regulatory small RNAs operate critical roles in brain activities including the neuronal clock activity. In this report, we propose the emergence of the earlier unexpected small RNAs for a historic perspective of epigenetic regulation of the brain clock system.
生物钟节律调控着睡眠、进食和能量消耗等基本生理活动，其由位于生物钟起搏器神经元中的光控中枢时钟基因所调节。具有独特转录和转录后反馈环的计时机制受大脑中不同的小调控 RNA 控制。多个神经元基因的作用，特别是转录后调控、剪接、多聚腺苷酸化、成熟 mRNA 编辑和翻译产物的稳定性，受通过小 RNA 协调的表观遗传活性所控制。总之，这些机制调节生物钟和光控基因以影响起搏器的活动和适应。生物钟电路、计时机制、定期适应的同步、振荡和节律的调节小 RNA 受多样化的 RNA 分子调控。调节小 RNA 在包括神经元生物钟活动在内的脑活动中发挥着关键作用。在本报告中，我们提出了早期未预料到的小 RNA 的出现，为脑时钟系统的表观遗传调控提供了历史视角。
