Department of Orthopaedic Surgery, School of Medicine, Keio University, Shinanomachi 35, Shinjuku-ku, Tokyo 160, Japan.
Restor Neurol Neurosci. 1997 Jan 1;11(1):65-9. doi: 10.3233/RNN-1997-111207.
Gaps, 10 mm wide, in rat sciatic nerves were bridged by bioartificial nerve grafts consisting of a silicone tube containing seven longitudinally placed synthetic filaments, which were expected to serve as a scaffold for axonal growth. The filaments were made of non-resorbable material (polyamide [Ethilon®]) or resorbable material (polydioxanon [PDS®], polyglactin [Vicryl®] or catgut). The purpose was to study the influence of resorbable materials on axonal regeneration and to choose, in the long term, the best filament material among the four. After 3 and 6 months, histological techniques were used to study the regenerated nerve structure. The total axon number in the nerve segment distal to the silicone chamber was counted in all specimens at 6 months. The histological findings were different depending on the filament materials; all the three resorbable materials showing significantly larger numbers of axons than polyamide (non-resorbable). All materials were covered with several layers of more or less flattened cells. These results indicate that resorbable filaments are superior to non-resorbable filaments when used as a scaffold inside a silicone tube, and polyglactin seems ideal for this purpose.
大鼠坐骨神经 10mm 宽的间隙用生物人工神经移植物桥接，生物人工神经移植物由一个含有 7 根纵向放置的合成纤维的硅酮管组成，预计这些纤维将作为轴突生长的支架。纤维由不可吸收材料（聚酰胺[Ethilon®]）或可吸收材料（聚二氧六环[PDS®]、聚乳酸[Vicryl®]或肠线）制成。目的是研究可吸收材料对轴突再生的影响，并在长期内从这四种材料中选择最佳的纤维材料。在 3 个月和 6 个月后，使用组织学技术研究再生神经的结构。所有标本在 6 个月时均计数硅酮室远端神经节段的总轴突数。组织学发现取决于纤维材料而有所不同；所有三种可吸收材料的轴突数量明显多于聚酰胺（不可吸收）。所有材料均被数层或多或少扁平的细胞覆盖。这些结果表明，当用作硅酮管内的支架时，可吸收纤维比不可吸收纤维优越，聚乳酸似乎是理想的材料。
