Department of Cell Biology and Physiology, School of Medicine, Universitat Autònoma de Barcelona, E-08193 Bellaterra, Spain.
Restor Neurol Neurosci. 1994 Jan 1;6(2):151-7. doi: 10.3233/RNN-1994-6209.
This study evaluates the degree of autotomy induced by anesthesia dolorosa after transection of the sciatic and saphenous nerves in four different strains of mice, and the effectiveness of amitriptyline administration in two of them. The self-mutilating lesions were assessed by means of an autotomy score for one month after denervation. The onset of lesions generally occurred during the first week, starting in the nails and progressing proximally. Autotomy behavior developed differently in the mouse strains studied, involving 88% of the paw areas in OF1 mice, 61% in Balb-C, 35% in NMRI, and 15% in B6CBAF1. Two selected strains, OF1 and NMRI, were treated with amitriptyline (8 mg/kg/day, p.o.) from different intervals pre-operation. Administration starting 14 days before nerve lesion was the most effective treatment schedule for reducing autotomy in both strains.
本研究评估了在 4 种不同品系的小鼠中，坐骨神经和隐神经切断术后疼痛诱导性自截的程度，以及阿米替林在其中 2 种品系中的给药效果。在神经切断后一个月，通过自截评分来评估自截损伤。损伤通常在第一周开始出现，从指甲开始向近端进展。在研究的小鼠品系中，自截行为的发展方式不同，OF1 小鼠的爪子区域有 88%受到影响，Balb-C 为 61%，NMRI 为 35%，B6CBAF1 为 15%。选择 OF1 和 NMRI 两种品系，用阿米替林（8mg/kg/天，口服）进行不同的术前干预时间。在神经损伤前 14 天开始给药的方案对两种品系的自截均有最有效的治疗效果。
