Qian Suhong, Fan Wenchun, Qian Ping, Zhang Dong, Wei Yurong, Chen Huanchun, Li Xiangmin
State Key Laboratory of Agricultural Microbiology, Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, Hubei, China.
Viruses. 2015 Mar 31;7(4):1613-26. doi: 10.3390/v7041613.
Foot-and-mouth disease (FMD) is a highly contagious disease of domestic and wild ruminants that is caused by FMD virus (FMDV). FMD outbreaks have occurred in livestock-containing regions worldwide. Apigenin, which is a flavonoid naturally existing in plant, possesses various pharmacological effects, including anti-inflammatory, anticancer, antioxidant and antiviral activities. Results show that apigenin can inhibit FMDV-mediated cytopathogenic effect and FMDV replication in vitro. Further studies demonstrate the following: (i) apigenin inhibits FMDV infection at the viral post-entry stage; (ii) apigenin does not exhibit direct extracellular virucidal activity; and (iii) apigenin interferes with the translational activity of FMDV driven by internal ribosome entry site. Studies on applying apigein in vivo are required for drug development and further identification of potential drug targets against FDMV infection.
口蹄疫（FMD）是由口蹄疫病毒（FMDV）引起的一种家养和野生反刍动物的高度传染性疾病。口蹄疫疫情已在全球有牲畜养殖的地区爆发。芹菜素是一种天然存在于植物中的黄酮类化合物，具有多种药理作用，包括抗炎、抗癌、抗氧化和抗病毒活性。结果表明，芹菜素在体外可抑制FMDV介导的细胞病变效应和FMDV复制。进一步研究表明：（i）芹菜素在病毒进入后阶段抑制FMDV感染；（ii）芹菜素不表现出直接的细胞外杀病毒活性；（iii）芹菜素干扰由内部核糖体进入位点驱动的FMDV的翻译活性。药物开发以及进一步鉴定针对FDMV感染的潜在药物靶点需要进行芹菜素的体内应用研究。
