Department of Hand Surgery, Malmö University Hospital, S-214 01 Malmö, Sweden.
Restor Neurol Neurosci. 1995 Jan 1;7(3):165-9. doi: 10.3233/RNN-1994-7306.
Regeneration distances were studied in nerves from vibration-exposed limbs. One hind limb of anaesthetized rats was attached to a vibration exciter and exposed to vibration (80 Hz/32 m/s2) for 5 h/day for 2 or 5 days. Seven days after the latest vibration period a 10-mm long nerve graft was taken from the vibrated sciatic nerve and sutured into a corresponding defect in the con-tralateral sciatic nerve and vice versa, thereby creating two different models within the same animal: (i) regeneration from a freshly transected unvibrated nerve into a vibrated graft and (ii) regeneration from a vibrated nerve into a fresh nerve graft (vibrated recipient side). Four, 6 or 8 days postoperatively (p.o.) the distances achieved by the regenerating axons were determined using the pinch reflex test. Two days of vibration did not influence the regeneration, but 5 days of vibration reduced the initial delay period and a slight reduction of regeneration rate was observed. After 5 days of vibration an increased regeneration distance was observed in both models at day 4 p.o. and at day 6 p.o. in vibrated grafts. This study demonstrates that vibration can condition peripheral nerves and this may be caused by local changes in the peripheral nerve trunk and in the neuron itself.
再生距离在受振动暴露的肢体神经中进行了研究。麻醉大鼠的一条后肢附着在振动激发器上，并每天暴露于振动（80 Hz/32 m/s2）5 小时，持续 2 或 5 天。在最近一次振动期后的第 7 天，从受振动的坐骨神经中取出 10mm 长的神经移植物，并缝合到对侧坐骨神经中的相应缺陷中，从而在同一动物中创建了两种不同的模型：（i）从新鲜横切的未振动神经再生到振动移植物，以及（ii）从振动神经再生到新鲜神经移植物（振动受者侧）。术后 4、6 或 8 天（p.o.），使用捏反射试验确定再生轴突达到的距离。2 天的振动不会影响再生，但 5 天的振动会缩短初始延迟期，并观察到再生率略有降低。在振动 5 天后，在两种模型中都观察到在 p.o.的第 4 天和振动移植物的第 6 天，再生距离增加。这项研究表明，振动可以调节周围神经，这可能是由周围神经干和神经元本身的局部变化引起的。
