Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan.
Restor Neurol Neurosci. 1995 Jan 1;9(1):1-5. doi: 10.3233/RNN-1995-9101.
The optimal time for nerve suture in transected rat sciatic nerve was investigated. The sciatic nerve on both side nerves were transected and repaired by an epineurial suture technique 0-28 days after nerve transection. The regeneration distance was measured by the sensory pinch reflex test 2-6 days after nerve repair. The initial delay period and the regeneration rate were calculated by using a new mathematical model. One day delayed repair was sufficient to reduce the initial delay period and the largest reduction on the initial delay period was observed in the three day delayed repair group. The initial delay period was reduced to 0.87 days as compared to 2.31 days for nerves repaired immediately (controls). The seven day and ten day delayed repair had similar effects but they also showed a decrease of the regeneration rate. The regeneration rate was not affected except for these two time points. The results suggest that the repair delay period can influence the initial delay as well as the regeneration rate. In our model an optimal effect was achieved on both these measures with a one or three day delay between transection and repair.
研究了大鼠坐骨神经切断后神经缝合的最佳时间。在神经切断后 0-28 天，通过神经外膜缝合技术对双侧坐骨神经进行了横断和修复。在神经修复后 2-6 天，通过感觉捏反射试验测量再生距离。使用新的数学模型计算初始延迟时间和再生速率。延迟一天修复足以减少初始延迟时间，而在延迟三天的修复组中观察到最大的初始延迟时间减少。与立即修复（对照）的 2.31 天相比，初始延迟时间减少到 0.87 天。延迟 7 天和 10 天修复具有相似的效果，但也显示出再生速率的降低。除了这两个时间点之外，再生速率不受影响。结果表明，修复延迟时间会影响初始延迟时间和再生速率。在我们的模型中，在横断和修复之间延迟 1 天或 3 天可在这两个指标上达到最佳效果。
