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老年人癫痫持续状态:鉴别诊断与治疗。

Status epilepticus in the elderly: differential diagnosis and treatment.

机构信息

Mayo Clinic, Jacksonville, FL, USA.

出版信息

Neuropsychiatr Dis Treat. 2011;7:161-6. doi: 10.2147/NDT.S10537. Epub 2011 Mar 29.

Abstract

Seizures are not an uncommon occurrence in older adults, and the incidence of status epilepticus is much greater in the elderly than in younger populations. Status epilepticus is a neurologic emergency and requires prompt intervention to minimize morbidity and mortality. Treatment involves both supportive care as well as initiation of medications to stop all clinical and electrographic seizure activity. Benzodiazepines are used as first-line agents, followed by antiepileptic drugs when seizures persist. In refractory status epilepticus, urgent neurologic consultation is indicated for the titration of anesthetic agents to a level of appropriate background suppression on EEG. In light of our aging population, physician awareness and competence in the management of status epilepticus is imperative and should be recognized as a growing public health concern.

摘要

老年人中癫痫发作并不少见,癫痫持续状态的发病率在老年人中比在年轻人中高得多。癫痫持续状态是一种神经系统急症,需要迅速干预,以最大限度地降低发病率和死亡率。治疗包括支持性护理以及启动药物治疗以停止所有临床和脑电图上的癫痫发作活动。苯二氮䓬类药物被用作一线药物,当癫痫持续存在时,再使用抗癫痫药物。在难治性癫痫持续状态中,需要紧急神经科会诊,以滴定麻醉药物至脑电图上适当的背景抑制水平。鉴于我们的人口老龄化,医生对癫痫持续状态的管理意识和能力至关重要,应被视为一个日益严重的公共卫生问题。

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本文引用的文献

1
Status epilepticus.癫痫持续状态
Continuum (Minneap Minn). 2010 Jun;16(3 Epilepsy):199-227. doi: 10.1212/01.CON.0000368239.87728.59.
2
EFNS guideline on the management of status epilepticus in adults.EFNS 成人癫痫持续状态管理指南。
Eur J Neurol. 2010 Mar;17(3):348-55. doi: 10.1111/j.1468-1331.2009.02917.x. Epub 2009 Dec 30.
9
It's time to revise the definition of status epilepticus.是时候修订癫痫持续状态的定义了。
Epilepsia. 1999 Jan;40(1):120-2. doi: 10.1111/j.1528-1157.1999.tb02000.x.

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