FR 900506对接受异位心脏同种异体移植大鼠的免疫抑制作用。
THE IMMUNOSUPPRESSIVE EFFECTS OF FR 900506 IN RATS RECEIVING HETEROTOPIC CARDIAC ALLOGRAFTS.
作者信息
Lee P, Murase N, Todo S, Makowka L, Starzl T
机构信息
Department of Surgery, 3601 Fifth Avenue, Falk Clinic 4 West, Pittsburgh, Pennsylvania 15213.
出版信息
Surg Res Commun. 1987;1:325-331.
Abstract
The immunosuppressive effects of FR 900506 were studied in Lewis rats given ACI heterotopic heart allografts. Intramuscular doses of 0.02 mg/kg daily for 2 weeks extended graft survival slightly, and with doses up to 1.28 mg/kg for 2 weeks, there is long-term graft survival. If only 3 daily doses were given starting on day 4 after transplantation, graft survival for almost 3 months was accomplished in 4 of 6 animals who still bear functioning hearts.
摘要
在接受 ACI 异位心脏异体移植的 Lewis 大鼠中研究了 FR 900506 的免疫抑制作用。每天肌肉注射剂量为 0.02 mg/kg，持续 2 周，可使移植物存活时间稍有延长；当剂量高达 1.28 mg/kg，持续 2 周时，移植物可长期存活。如果在移植后第 4 天开始仅给予 3 次每日剂量，则 6 只动物中有 4 只的移植物存活了近 3 个月，这些动物的心脏仍在正常工作。
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本文引用的文献
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Effect of a new immunosuppressive agent, FK 506, on heterotopic cardiac allotransplantation in the rat.新型免疫抑制剂FK 506对大鼠异位心脏同种异体移植的影响。
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