FK506在实验性器官移植中的作用。
Effect of FK506 in experimental organ transplantation.
作者信息
Todo S, Murase N, Ueda Y, Podesta L, ChapChap P, Kahn D, Okuda K, Imventarza O, Casavilla A, Demetris J
机构信息
Department of Surgery, University Health Center of Pittsburgh, University of Pittsburgh, PA 15213.
出版信息
Transplant Proc. 1988 Feb;20(1 Suppl 1):215-9.
Abstract
FK506 is the most potent immunosuppressive agent known. Its toxicity is substantial in dogs, minor in rats, and unknown in subhuman primates. In small doses that are nontoxic even in dogs, it can be used in synergistic combination with cyclosporine, steroids, and presumably in other drugs.
摘要
FK506是已知最强效的免疫抑制剂。它对犬类毒性很大，对大鼠毒性较小，对非人灵长类动物的毒性未知。在即使对犬类也无毒的小剂量下，它可与环孢素、类固醇以及可能与其他药物联合使用。
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