FR 900506用于犬肾和肝移植的免疫抑制作用
IMMUNOSUPPRESSION WITH FR 900506 FOR CANINE KIDNEY AND LIVER TRANSPLANTATION.
作者信息
Todo S, Makowka L, Starzl T
机构信息
Department of Surgery, University of Pittsburgh Health Center, University of Pittsburgh, Pittsburgh, Pennsylvania.
出版信息
Surg Res Commun. 1987 Jan 1;1:333-340.
Abstract
The immunosuppressive effects of FR 900506 were investigated for one month after canine kidney and liver transplantation. Eight untreated kidney recipients lived for 8 to 19 days, mean 12.1. In contrast, the one month survival of dogs given FR 900506 in daily oral doses of 0.5, 1.0, and 1.5 mg/kg was 2/6, 3/6, and 4/6 respectively. The one month survival of liver recipients was 4/5 compared to one month survival of 1/8 in historical untreated controls. There was no evidence from biochemical tests of hepatotoxicity or nephrotoxicity.
摘要
在犬肾和肝移植后，对FR 900506的免疫抑制作用进行了为期一个月的研究。八只未接受治疗的肾移植受体存活了8至19天，平均为12.1天。相比之下，每日口服剂量为0.5、1.0和1.5mg/kg的FR 900506的犬的一个月存活率分别为2/6、3/6和4/6。肝移植受体的一个月存活率为4/5，而历史上未治疗的对照组的一个月存活率为1/8。生化测试没有证据表明存在肝毒性或肾毒性。
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