Sherman Simon, Shats Oleg, Ketcham Marsha A, Anderson Michelle A, Whitcomb David C, Lynch Henry T, Ghiorzo Paola, Rubinstein Wendy S, Sasson Aaron R, Grizzle William E, Haynatzki Gleb, Feng Jianmin, Sherman Alexander, Kinarsky Leo, Brand Randall E
Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, NE, USA.
Cancer Inform. 2011 Mar 23;10:83-91. doi: 10.4137/CIN.S6919.
The Pancreatic Cancer Collaborative Registry (PCCR) is a multi-institutional web-based system aimed to collect a variety of data on pancreatic cancer patients and high-risk subjects in a standard and efficient way. The PCCR was initiated by a group of experts in medical oncology, gastroenterology, genetics, pathology, epidemiology, nutrition, and computer science with the goal of facilitating rapid and uniform collection of critical information and biological samples to be used in developing diagnostic, prevention and treatment strategies against pancreatic cancer. The PCCR is a multi-tier web application that utilizes Java/JSP technology and has Oracle 10 g database as a back-end. The PCCR uses a "confederation model" that encourages participation of any interested center, irrespective of its size or location. The PCCR utilizes a standardized approach to data collection and reporting, and uses extensive validation procedures to prevent entering erroneous data. The PCCR controlled vocabulary is harmonized with the NCI Thesaurus (NCIt) or Systematized Nomenclature of Medicine-Clinical Terms (SNOMED-CT). The PCCR questionnaire has accommodated standards accepted in cancer research and healthcare. Currently, seven cancer centers in the USA, as well as one center in Italy are participating in the PCCR. At present, the PCCR database contains data on more than 2,700 subjects (PC patients and individuals at high risk of getting this disease). The PCCR has been certified by the NCI Center for Biomedical Informatics and Information Technology as a cancer Biomedical Informatics Grid (caBIG(®)) Bronze Compatible product. The PCCR provides a foundation for collaborative PC research. It has all the necessary prerequisites for subsequent evolution of the developed infrastructure from simply gathering PC-related data into a biomedical computing platform vital for successful PC studies, care and treatment. Studies utilizing data collected in the PCCR may engender new approaches to disease prognosis, risk factor assessment, and therapeutic interventions.
胰腺癌协作登记处（PCCR）是一个基于网络的多机构系统，旨在以标准、高效的方式收集胰腺癌患者和高危人群的各种数据。PCCR由一组医学肿瘤学、胃肠病学、遗传学、病理学、流行病学、营养学和计算机科学领域的专家发起，目的是促进快速、统一地收集关键信息和生物样本，用于制定胰腺癌的诊断、预防和治疗策略。PCCR是一个多层网络应用程序，采用Java/JSP技术，后端使用Oracle 10g数据库。PCCR采用“联盟模式”，鼓励任何感兴趣的中心参与，无论其规模或位置如何。PCCR采用标准化的数据收集和报告方法，并使用广泛的验证程序来防止输入错误数据。PCCR控制词汇与美国国立癌症研究所术语表（NCIt）或医学临床术语系统化命名法（SNOMED-CT）保持一致。PCCR问卷符合癌症研究和医疗保健领域公认的标准。目前，美国的七个癌症中心以及意大利的一个中心正在参与PCCR。目前，PCCR数据库包含2700多名受试者（胰腺癌患者和患此病高危个体）的数据。PCCR已被美国国立癌症研究所生物医学信息学和信息技术中心认证为癌症生物医学信息网格（caBIG(®)）青铜兼容产品。PCCR为胰腺癌协作研究提供了基础。它具备将已开发的基础设施从简单收集与胰腺癌相关的数据演变为对成功开展胰腺癌研究、护理和治疗至关重要的生物医学计算平台的所有必要先决条件。利用PCCR收集的数据进行的研究可能会产生疾病预后、风险因素评估和治疗干预的新方法。
