Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0879, Japan.
Org Biomol Chem. 2011 Jun 21;9(12):4425-8. doi: 10.1039/c1ob05489a. Epub 2011 May 6.
The asymmetric alkynylation of aliphatic and aromatic aldehydes with propiolates was mediated by dialkylzinc and a novel prolinol catalyst without high reagent loading and any additives, such as Ti(Oi-Pr)(4), to give the corresponding γ-hydroxy-α,β-acetylenic esters with high enantiomeric excess of up to 95%.
二烷基锌和新型脯醇催化剂介导的丙炔酸酯与脂肪族和芳香族醛的不对称炔丙基化反应，无需高试剂负载和任何添加剂（如 Ti(Oi-Pr)(4)），即可得到相应的γ-羟基-α,β-炔基酯，对映过量高达 95%。
