Nakamura S, Nishiwaki Y, Suzuki S, Sakaguchi S, Yamashita Y, Ohta K
Second Department of Surgery, Hamamatsu University School of Medicine, Japan.
Lasers Surg Med. 1990;10(1):12-5. doi: 10.1002/lsm.1900100105.
The attenuation of light in the human liver and hepatic tumors was measured in the 410-, 630-, and 670-nm wavelengths. Optical fibers coupled to a photon-counting system were positioned within the tissues to determine the light flux and were attached to a caliper gauge to measure the fiber separation distance. Five resected specimens each of metastatic carcinoma from the colon with normal liver and hepatocellular carcinoma with cirrhosis of the liver were used immediately after surgical resection. Metastatic tumors showed the deepest penetration at all wavelengths. A significant difference appeared between the cancerous and noncancerous tissues (P less than .01). Additionally, the cirrhotic liver tissues showed significant deep penetration by all wavelengths examined in comparison with normal liver tissues (P less than .01). The implications of light dosimetry for clinical application from the results of our study are discussed.
在410纳米、630纳米和670纳米波长下测量了人肝脏和肝肿瘤中的光衰减。与光子计数系统耦合的光纤放置在组织内以确定光通量，并连接到卡尺以测量光纤分离距离。五个结肠转移癌伴正常肝脏以及肝细胞癌伴肝硬化的切除标本在手术切除后立即使用。转移瘤在所有波长下均显示出最深的穿透。癌组织和非癌组织之间存在显著差异（P小于0.01）。此外，与正常肝组织相比，肝硬化肝组织在所有检测波长下均显示出显著的深度穿透（P小于0.01）。讨论了本研究结果对光剂量学临床应用的意义。
