Department of Biomaterials and Experimental Dentistry, University of Medical Sciences, Poznan, Poland.
World J Biol Psychiatry. 2011 Jun;12(4):282-7. doi: 10.3109/15622975.2010.540256.
The current study established whether vomiting bulimic and/or non-bulimic depressive patients, both treated with a serotonin reuptake inhibitor (fluoxetine), have changes in their whole salivary secretion and inorganic components: Na(+), K(+), Ca(2+).
From 108 female subjects, namely bulimics (Group B) (fluoxetine: 40 mg/day) (n=33), non-bulimic depressives (Group D) (fluoxetine: 20 mg/day) (n=25) and a Group C of 50 healthy controls, unstimulated and stimulated saliva was collected. The concentrations of Na(+), K(+), Ca(2+) were determined by colorimetric photometry method (Effox 5053, Eppendorf, Germany).
The bulimic group reported significant lower output in salivary flow and sodium concentration. In the group (D) only flow was lower than in healthy controls but not significant.
This study supports the hypothesis that salivary flow is an unreliable indicator of bulimia, the lack of increase in sodium level in stimulated saliva in bulimic subjects could be a more reliable confirmation of the eating disorder.
本研究旨在探讨接受选择性 5-羟色胺再摄取抑制剂（氟西汀）治疗的呕吐性贪食症和/或非贪食性抑郁症患者的全唾液分泌和无机成分（Na+、K+、Ca2+）是否发生变化。
从 108 名女性受试者中，即贪食症患者（B 组）（氟西汀：40mg/天）（n=33）、非贪食性抑郁症患者（D 组）（氟西汀：20mg/天）（n=25）和 50 名健康对照组（C 组）中，采集非刺激性和刺激性唾液。采用比色光度法（Effox 5053，Eppendorf，德国）测定 Na+、K+、Ca2+的浓度。
贪食症组唾液流量和钠浓度显著降低。D 组仅唾液流量低于健康对照组，但无统计学意义。
本研究支持唾液流量不能可靠地指示贪食症的假说，刺激唾液中钠水平无增加可能是对该饮食失调症更可靠的确认。
