Department of Neuroscience; Georgetown University Medical Center, 3970 Reservoir Rd, NW, Washington, DC, 20007, USA.
Mol Neurodegener. 2011 May 9;6:30. doi: 10.1186/1750-1326-6-30.
Very Low Density Lipoprotein Receptor (VLDLR) and Apolipoprotein E Receptor 2 (ApoER2) are important receptors in the brain for mediating the signaling effects of the extracellular matrix protein Reelin, affecting neuronal function in development and in the adult brain. VLDLR and ApoER2 are members of the low density lipoprotein family, which also mediates the effects of numerous other extracellular ligands, including apolipoprotein E. Although VLDLR and ApoER2 are highly homologous, they differ in a number of ways, including structural differences, expression patterns, alternative splicing, and binding of extracellular and intracellular proteins. This review aims to summarize important aspects of VLDLR and ApoER2 that may account for interesting recent findings that highlight the unique functions of each receptor.
极低密度脂蛋白受体 (VLDLR) 和载脂蛋白 E 受体 2 (ApoER2) 是大脑中重要的受体，可介导细胞外基质蛋白 Reelin 的信号作用，影响发育中和成年期大脑中的神经元功能。VLDLR 和 ApoER2 是低密度脂蛋白家族的成员，该家族还介导许多其他细胞外配体的作用，包括载脂蛋白 E。尽管 VLDLR 和 ApoER2 高度同源，但它们在结构差异、表达模式、选择性剪接以及细胞外和细胞内蛋白的结合等方面存在差异。本综述旨在总结 VLDLR 和 ApoER2 的重要方面，这些方面可能解释了最近的一些有趣发现，这些发现强调了每个受体的独特功能。
