Mihail A, Coman G, Staniceanu F, Coman L, Zurac S, Coman O A
Department of Dermatology, "Dr. Victor Babeş" Clinical Hospital of Infectious and Tropical Diseases, Bucharest, Romania ; Department of Dermatology, "Titu Maiorescu" University, Bucharest, Romania.
Department of Dermatology, "Dr. Victor Babeş" Clinical Hospital of Infectious and Tropical Diseases, Bucharest, Romania.
J Med Life. 2017 Jan-Mar;10(1):85-89.
Reelin is an extracellular signaling protein synthesized by Cajal-Retius cells in utero and early after birth, its presence being signaled in adult life too. Reelin acts on its receptors, VLDLR and ApoER2, acting on cytoskeleton, controlling migration and subsequently positioning and stabilizing the cortical neurons. We investigated the reelin presence and its receptors, VLDLR and ApoER2, in melanocytic nevi considering the neural crest origin of the nevus cells and their migration into skin during embrionary period. Melanocytic nevi present a strict cellular architecture and an increased malignant transforming capacity. We investigated reelin presence in 32 melanocytic nevi (5 junctional, 27 compound or 14 dysplastic nevi and 18 non dysplastic nevi). The assessment of reelin presence was performed by histological semiquantitative criteria. Results showed the presence of reelin in 29 cases (29/ 32). The presence of reelin was elevated in junctional areas as in dysplastic nevi. VLDLR presented positive values in 16 cases (16/ 32) and ApoER2 was weak positive in 7 cases. Reelin or its receptors was peritumorally absent. Our study showed the presence of reelin in nevus cells from cutaneous melanocytic nevi and, in these cells, only the VLDLR receptor was present in half of the cases. The significance of the reelin presence in cutaneous nevus cells may be hypothetically considered correlated with the position maintenance of the nevus cells or migration of these cells in malignant transforming situation. ApoER2 = apolipoprotein receptor 2, VLDLR = very low density lipoprotein receptor, DAB-1 = DIABLO protein, HMB45 = gene HMB45.
Reelin是一种细胞外信号蛋白，由子宫内和出生后早期的Cajal-Retius细胞合成，在成年期也有表达。Reelin作用于其受体VLDLR和ApoER2，作用于细胞骨架，控制迁移，随后定位并稳定皮质神经元。考虑到痣细胞的神经嵴起源及其在胚胎期迁移到皮肤中，我们研究了黑素细胞痣中Reelin及其受体VLDLR和ApoER2的存在情况。黑素细胞痣呈现出严格的细胞结构和增加的恶性转化能力。我们研究了32例黑素细胞痣（5例交界痣、27例复合痣或14例发育异常痣和18例非发育异常痣）中Reelin的存在情况。通过组织学半定量标准对Reelin的存在情况进行评估。结果显示29例（29/32）存在Reelin。在交界区和发育异常痣中Reelin的表达升高。VLDLR在16例（16/32）中呈阳性，ApoER2在7例中呈弱阳性。肿瘤周围不存在Reelin或其受体。我们的研究表明皮肤黑素细胞痣的痣细胞中存在Reelin，并且在这些细胞中，仅一半病例存在VLDLR受体。皮肤痣细胞中Reelin存在的意义可能被假设与痣细胞的位置维持或这些细胞在恶性转化情况下的迁移相关。ApoER2 = 载脂蛋白受体2，VLDLR = 极低密度脂蛋白受体，DAB-1 = DIABLO蛋白，HMB45 = 基因HMB45
