大肠杆菌五种热不稳定毒性产物的比较研究。
Comparative studies of five heat-labile toxic products of Escherichia coli.
作者信息
Konowalchuk J, Dickie N, Stavric S, Speirs J I
出版信息
Infect Immun. 1978 Dec;22(3):644-8. doi: 10.1128/iai.22.3.644-648.1978.
Abstract
Five heat-labile, partially purified toxic products of Escherichia coli were distinguished by isoelectric focusing, molecular weight, and neutralization with homologous and heterologous antisera. Only two affected the morphology of Y-1 cells, induced fluid accumulation in rabbit ileal loops, and stimulated production of cyclic AMP in Vero cells; these two did not cross-neutralize and only one showed cross-neutralization with cholera antitoxin. The remaining three products were cytotoxic for Vero cells.
摘要
通过等电聚焦、分子量以及用同源和异源抗血清进行中和反应，区分出了大肠杆菌的五种热不稳定、部分纯化的毒性产物。只有两种产物会影响Y-1细胞的形态，在兔回肠袢中诱导液体蓄积，并刺激Vero细胞中环状AMP的产生；这两种产物不能交叉中和，且只有一种与霍乱抗毒素表现出交叉中和反应。其余三种产物对Vero细胞具有细胞毒性。
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