de Kanter Clara T M M, Keuter Monique, van der Lee Manon J, Koopmans Peter P, Burger David M
Department of Clinical Pharmacy, Radboud University Nijmegen Medical Center, the Netherlands.
Antivir Ther. 2011;16(3):435-7. doi: 10.3851/IMP1747.
The authors describe an HIV-infected patient with moderate renal failure receiving combination antiretroviral therapy. Because of dyslipidaemia he was initially treated with pravastatin but developed rhabdomyolysis after a switch to rosuvastatin. With this case we illustrate that statins as well as antiretroviral therapy are susceptible to clinical relevant drug-drug or drug-disease interactions. Knowledge of these interactions is important to provide patients with the best possible care.
作者描述了一名接受联合抗逆转录病毒治疗的中度肾衰竭HIV感染患者。由于血脂异常，他最初接受普伐他汀治疗，但在换用瑞舒伐他汀后发生了横纹肌溶解。通过这个病例，我们表明他汀类药物以及抗逆转录病毒治疗都容易出现临床相关的药物-药物或药物-疾病相互作用。了解这些相互作用对于为患者提供尽可能最佳的治疗很重要。
