Amsterdam J D, Maislin G, Rybakowski J
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia.
Biol Psychiatry. 1990 Feb 15;27(4):447-53. doi: 10.1016/0006-3223(90)90555-g.
There has been considerable interest in the possibility that some psychotropic medications may possess antiviral activity. Several clinical observations suggest that lithium may inhibit the reactivation of latent herpes simplex virus, thereby reducing the number of recurrent infections. We performed a retrospective study examining the putative antiviral activity of various psychotropic agents in 177 subjects receiving lithium prophylaxis and a comparison group of 59 subjects receiving other antidepressant drugs for affective illness. Chronic lithium administration resulted in a significant reduction in the mean rate of recurrent labial herpes infections when compared to the pretreatment period (p less than 0.001). In contrast, the mean rate of herpes infections was unchanged in patients taking other antidepressants (p = 0.53). Although the overall reduction in herpes infections was not significantly different between groups, the proportion of subjects reporting a reduction in infection rate was greater in the lithium group (71%) compared with those receiving other antidepressants (52%) (p = 0.07). These data compliment prior in vitro and clinical studies demonstrating a potential antiviral activity for lithium carbonate.
一些精神药物可能具有抗病毒活性，这一可能性已引发了相当大的关注。多项临床观察表明，锂可能会抑制潜伏性单纯疱疹病毒的再激活，从而减少复发性感染的次数。我们进行了一项回顾性研究，考察了177名接受锂预防治疗的受试者以及59名接受其他抗抑郁药物治疗情感疾病的对照组受试者中各种精神药物的假定抗病毒活性。与治疗前期相比，长期服用锂导致复发性唇疱疹感染的平均发生率显著降低（p<0.001）。相比之下，服用其他抗抑郁药物的患者疱疹感染的平均发生率没有变化（p = 0.53）。虽然两组之间疱疹感染的总体减少没有显著差异，但报告感染率降低的受试者比例在锂治疗组（71%）高于接受其他抗抑郁药物治疗的组（52%）（p = 0.07）。这些数据补充了先前的体外和临床研究，证明碳酸锂具有潜在的抗病毒活性。
