Parasitology Department, Institute of Tropical Medicine Antwerp, Nationalestraat 155, Antwerp-2000, Belgium.
Infect Genet Evol. 2011 Dec;11(8):2113-8. doi: 10.1016/j.meegid.2011.04.026. Epub 2011 Apr 30.
Natural hybridization events have been demonstrated between closely and distantly related Leishmania groups despite a predominantly clonal and endogamically sexual mode of reproduction. Here we report the first natural hybrid between Leishmania aethiopica and Leishmania donovani, as evidenced from the analysis of several clones from strain MHOM/ET/94/ABAUY. Targeted species-identification PCRs revealed the presence of both genotypes, and amplified fragment length polymorphisms indicated that the clones are genetically in an intermediate position between both parental species, being more closely related to L. aethiopica. The possible scenario facilitating hybrid formation is not clear, but is discussed in relation to epidemiological data.
尽管存在主要的无性和内婚性繁殖方式，但在密切和远缘利什曼原虫群之间已经证明存在自然杂交事件。在这里，我们报告了利什曼原虫埃塞俄比亚种和利什曼原虫杜氏利什曼原虫之间的首例自然杂交，这一点从对来自株 MHOM/ET/94/ABAUY 的几个克隆的分析中得到了证明。针对特定物种的鉴定 PCR 显示存在两种基因型，扩增片段长度多态性表明这些克隆在遗传上处于两个亲本种之间的中间位置，与利什曼原虫埃塞俄比亚种更为密切相关。促成杂交形成的可能情况尚不清楚，但将其与流行病学数据相关联进行了讨论。
