Tsukamoto Atsushi, Ohno Koichi, Tsukagoshi Taro, Maeda Shingo, Nakashima Ko, Fukushima Kenjiro, Fujino Yasuhito, Tsujimoto Hajime
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan.
J Vet Med Sci. 2011 Sep;73(9):1133-8. doi: 10.1292/jvms.11-0044. Epub 2011 May 10.
Gastric motility is affected by several pathological conditions which may induce upper gastrointestinal clinical symptoms. The pathogenesis of canine gastric motility disorders is poorly understood because of methodological limitations. This study aimed at establishing a simple method for evaluating postprandial gastric motility in dogs. Gastric motility was ultrasonographically assessed in 7 healthy beagles using a technique previously described in humans. The motility index (MI), an indicator of gastric antral motility, was calculated by measuring the area of the gastric antrum in both a contracted and relaxed phase and by counting the number of contractions. The MI was measured every 30 min for 3 hr after feeding and compared with gastric emptying as assessed by a (13)C-octanoic acid breath test. The MI at 30 min had the lowest variability in the 7 dogs (mean SD, 9.77 ± 0.42; coefficient of variance, 4.25%), and a significant correlation was observed with gastric emptying coefficient (R(2)=0.8126, P=0.005) and half-emptying time (R(2)=0.654, P=0.027). When atropine was administered, a significant decrease in the MI at 30 min was observed compared with the control (9.77 ± 0.42 vs. 5.19 ± 0.22, P=0.0003). In conclusion, evaluation of the MI at 30 min is suitable for assessing gastric motility and enables us to assess gastric motility simply in a short time. By using this method, further studies for the pathogenesis of canine gastric motility disorders are warranted.
胃动力受多种病理状况影响，这些状况可能诱发上消化道临床症状。由于方法学上的限制，犬胃动力障碍的发病机制尚不清楚。本研究旨在建立一种评估犬餐后胃动力的简单方法。使用先前在人类中描述的技术，对7只健康的比格犬进行超声评估胃动力。通过测量胃窦收缩期和舒张期的面积并计算收缩次数，计算出作为胃窦动力指标的动力指数（MI）。喂食后每30分钟测量一次MI，持续3小时，并与通过（13）C-辛酸呼气试验评估的胃排空进行比较。7只犬在30分钟时的MI变异性最低（平均标准差，9.77±0.42；变异系数，4.25%），并且与胃排空系数（R2 = 0.8126，P = 0.005）和半排空时间（R2 = 0.654，P = 0.027）观察到显著相关性。当给予阿托品时，与对照组相比，30分钟时的MI显著降低（9.77±0.42对5.19±0.22，P = 0.0003）。总之，评估30分钟时的MI适用于评估胃动力，并使我们能够在短时间内简单地评估胃动力。通过使用这种方法，有必要对犬胃动力障碍的发病机制进行进一步研究。
