Guo W-J, Yao S-K, Zhang Y-L, Du S-Y, Wang H-F, Yin L-J, Li H-L
1 Department of Gastroenterology, 36635 China-Japan Friendship Hospital , Beijing, China.
2 Department of Nuclear Medicine, 36635 China-Japan Friendship Hospital , Beijing, China.
J Int Med Res. 2018 Feb;46(2):792-801. doi: 10.1177/0300060517726442. Epub 2017 Sep 5.
Objective This study was performed to investigate impaired vagal activity to meal in patients with functional dyspepsia (FD) with delayed gastric emptying (GE). Methods Eighty-five patients were studied. GE parameters, including those in the overall and proximal stomach, were measured by GE functional tests at the Department of Nuclear Medicine. Autonomic nervous function was tested by spectral analysis of heart rate variability (HRV). The vagal activity and sympathetic activity were analyzed by recording the power in the high-frequency component (HF), low-frequency component (LF), and LF/HF ratio. Results Overall and proximal GE were delayed in 47.2% and 50.9% of the patients, respectively. Spectral analysis of HRV showed that the HF in patients with delayed proximal GE was significantly lower and that the LF/HF ratio was significantly higher than those in patients with normal proximal GE after a meal. Conclusion Delayed proximal GE might be caused by disrupted sympathovagal balance as a result of decreased vagal activity after a meal. Improvement in vagal activity may constitute an effective treatment method for patients with FD.
目的 本研究旨在调查伴有胃排空延迟（GE）的功能性消化不良（FD）患者进餐时迷走神经活动受损情况。方法 对85例患者进行研究。通过核医学科的GE功能测试测量GE参数，包括全胃和近端胃的参数。通过心率变异性（HRV）频谱分析测试自主神经功能。通过记录高频成分（HF）、低频成分（LF）的功率以及LF/HF比值来分析迷走神经活动和交感神经活动。结果 分别有47.2%和50.9%的患者全胃和近端胃GE延迟。HRV频谱分析显示，近端GE延迟患者餐后的HF显著降低，LF/HF比值显著高于近端GE正常的患者。结论 近端GE延迟可能是由于进餐后迷走神经活动降低导致交感迷走神经平衡失调所致。改善迷走神经活动可能是FD患者的一种有效治疗方法。
