Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA.
Trends Endocrinol Metab. 2011 Aug;22(8):325-32. doi: 10.1016/j.tem.2011.03.007. Epub 2011 May 10.
Twenty years ago, adipocytes were largely considered to be inert energy-storage depots. We now know that fat cells are highly insulin-sensitive with significant endocrine functions. Alterations in adipocyte development or function can contribute to metabolic disease, in particular type 2 diabetes. The current obesity epidemic that plagues many nations provides a strong rationale for understanding basic adipocyte biology. The JAK-STAT signaling pathway mediates the action of a variety of hormones that have profound effects on adipocyte development and function. In addition, adipocytes secrete hormones that utilize this signaling pathway. This review summarizes research on the expression and function of JAKs and STATs in adipocytes and highlights the roles of JAK-STAT-activating cytokines in adipose tissue.
二十年前，脂肪细胞在很大程度上被认为是惰性的储能库。我们现在知道，脂肪细胞对胰岛素高度敏感，具有重要的内分泌功能。脂肪细胞发育或功能的改变可导致代谢疾病，特别是 2 型糖尿病。目前困扰许多国家的肥胖症流行提供了一个很好的理由来理解基础脂肪细胞生物学。JAK-STAT 信号通路介导了多种激素的作用，这些激素对脂肪细胞的发育和功能有深远的影响。此外，脂肪细胞分泌利用这种信号通路的激素。这篇综述总结了 JAK 和 STAT 在脂肪细胞中的表达和功能的研究，并强调了 JAK-STAT 激活细胞因子在脂肪组织中的作用。
